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Amine Derivative Having NPY Y5 Receptor Antagonistic Activity

  • US 20100063027A1
  • Filed: 04/25/2007
  • Published: 03/11/2010
  • Est. Priority Date: 04/28/2006
  • Status: Active Grant
First Claim
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1. A compound of the formula (I):

  • a pharmaceutically acceptable salt or solvate thereof, whereinR1 is optionally substituted lower alkyl,Y is —

    S(O)n

    wherein n is 1 or 2, or —

    CO—

    ,R2 is hydrogen or optionally substituted lower alkyl,R1 and R2 taken together may form lower alkylene,R7 is hydrogen or optionally substituted lower alkyl,X is optionally substituted lower alkylene,optionally substituted lower alkenylene,optionally substituted —

    CO-lower alkylene,optionally substituted —

    CO-lower alkenylene or a group of the formula;

    whereinR3, R4, R5 and R6 are each independently hydrogen or optionally substituted lower alkyl, a group of the formula;

    is optionally substituted cycloalkylene, optionally substituted cycloalkenylene, optionally substituted bicycloalkylene, optionally substituted arylene or optionally substituted heterocyclyldiyl,p and q are each independently an integer between 0 and 2, either p or q is not 0, provided that a group of the formula;

    is not a group of the formula;

    wherein R14 is optionally substituted phenyl, —

    NR2

    X—

    may be a group of the formula;

    wherein a group of the formula;

    is piperidinediyl, piperazinediyl, pyridindiyl, pyrazinediyl, pyrrolidinediyl or pyrrolediyl,U is lower alkylene or lower alkenylene, andZ is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted amino, optionally substituted lower alkoxy, optionally substituted carbocyclyl or optionally substituted heterocyclyl,provided that Z is not fused heterocyclyl consisting of three rings, optionally substituted thiazolyl or optionally substituted quinazolinyl, andprovided that a compound wherein X is a group of the formula;

    a group of the formula;

    is optionally substituted cycloalkylene, q is 1, q is 0 and Z is optionally substituted pyrimidinyl is excluded.

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