SWEAT COLLECTION DEVICES FOR GLUCOSE MEASUREMENT

• US 20100063372A1
• Filed: 09/08/2009
• Published: 03/11/2010
• Est. Priority Date: 09/09/2008
• Status: Abandoned Application

• Current Assignee: Hiroshi Yanazawa, Irina Finkelshtein, James W. Moyer, Russell O. Potts, Shuying Ye
• Original Assignee: Hiroshi Yanazawa, Irina Finkelshtein, James W. Moyer, Russell O. Potts, Shuying Ye
• Inventors: Ye, Shuying, Finkelshtein, Irina, POTTS, Russell O., Yanazawa, Hiroshi, Moyer, James W.
• Application Number:
  US12/555,718
• Publication Number:
  US 20100063372A1
• Time in Patent Office: Days
• US Class Current: 600/346
• CPC Class Codes: A61B 5/14521 using means for promoting sweat production, e.g. heating the skin measuring sweat secretion A61B5/4266
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6833 Adhesive patches

Abstract

Devices, methods, and kits for collecting sweat that has come to the surface of the skin are provided. The sweat may be collected for measuring sweat glucose levels. Because sweat glucose levels correlate to blood glucose levels, the provided devices, methods, and kits may be used by diabetic patients to non-invasively monitor blood glucose levels. Sweat collection devices may be attachable to the surface of the skin and may collect about one microliter or less of sweat. Because only a small, fixed volume of sweat may be collected, the sweat glucose level may be measured in a matter of minutes. Further, as a fixed volume of sweat is tested, inaccuracies due to estimates of the sweat volume being tested are less likely to cause an inaccurate glucose measurement.

Claims

1. A device comprising:

a channel layer configured to direct sweat that has come to the skin surface to an opening;

a container layer in fluid communication with the opening and defining at least a portion of a container configured to contain a volume of less than about one microliter of the sweat; and

a vent layer comprising a vent adjacent to the container.

2. The device of claim 1, wherein the channel layer comprises a plurality of channels, each of the channels in fluid communication with the opening.

3. The device of claim 1, wherein the channel layer defines at least a portion of a bottom side of the container.

4. The device of claim 3, wherein the channel layer comprises an electrode in contact with the container.

5. The device of claim 1, wherein the opening has a diameter of less than about seven hundred micrometers.

6. The device of claim 1, wherein the volume of the container is fixed.

7. The device of claim 1, wherein the container layer comprises an electrode in contact with the container.

8. The device of claim 1, wherein the vent is hydrophobic.

9. The device of claim 1, wherein the vent is configured to reduce evaporation from the container.

10. The device of claim 1, wherein an external surface of the vent layer comprises external electrodes configured to contact a measurement device, each of the external electrodes connected to an internal electrode in contact with the container.

11. The device of claim 1, wherein the vent layer has a thickness of approximately 500 micrometers.

12. The device of claim 1, wherein the vent layer defines at least a portion of a top side of the container.

13. The device of claim 1, wherein the vent layer comprises one or more electrodes in contact with the container.

14. The device of claim 1, wherein the channel layer comprises a mechanism to induce the sweat.

15. The device of claim 1, wherein the container comprises glucose oxidase.

16. The device of claim 1, wherein the container comprises a dye.

17. The device of claim 1, wherein the device can be used with a measurement device when the container contains the volume of the sweat.

18. The device of claim 1, wherein the channel layer has a thickness of about 200 micrometers.

19. The device of claim 1, wherein the container layer has a thickness of about 200 micrometers.

20. The device of claim 1, wherein the container layer defines a side portion of the container.

21. A method for measuring glucose comprising:

collecting a predetermined volume of sweat from skin using a skin patch, wherein the volume is less than about one microliter of sweat; and

measuring an amount of glucose in the volume of the sweat.

22. The method of claim 21, further comprising stimulating sweat production.

23. The method of claim 21, further comprising determining whether the volume of the sweat is adequate prior to measuring the amount of the glucose.

24. The method of claim 21, wherein measuring the amount of the glucose comprises contacting the skin patch with a measurement device.

25. A kit comprising:

a skin patch configured to collect a predetermined volume of sweat, wherein the predetermined volume is less than about one microliter; and

a measurement device configured to measure an amount of glucose in the sweat, wherein the measurement is based on the predetermined volume.

26. The kit of claim 25, wherein the skin patch comprises a container configured to contain the predetermined volume.

27. The kit of claim 26, wherein the container is configured to retain its shape if the skin patch is deformed.

28. The kit of claim 25, wherein the skin patch comprises at least two electrodes in contact with the container.

29. The kit of claim 25, wherein the skin patch is configured to provide an indication if the predetermined volume is collected.

30. The kit of claim 25, wherein the skin patch is configured for single use.

31. The kit of claim 25, further comprising a plurality of the skin patches.

32. The kit of claim 25, wherein the measurement device comprises at least two electrodes configured to contact the skin patch.

33. The kit of claim 25, wherein the measurement device comprises an inlet configured to receive the skin patch.