MICROBURST ELECTRICAL STIMULATION OF CRANIAL NERVES FOR THE TREATMENT OF MEDICAL CONDITIONS
First Claim
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1. A method of treating a medical condition comprising:
- applying to a vagus nerve of the patient a pulsed electrical signal comprising a plurality of microbursts, wherein each microburst is characterized by;
from 2 to 15 pulses per microburst;
an interpulse interval between adjacent pulses of the microburst of from 1 to 20 milliseconds; and
a microburst duration of not greater than 1 second;
wherein each microburst is separated from an adjacent microburst by an interburst period of at least 100 milliseconds.
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Abstract
Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device by applying an electrical signal characterized by having a number of pulses per microburst, an interpulse interval, a microburst duration, and an interburst period to a portion of a cranial nerve of said patient, wherein at least one of the number of pulses per microburst, the interpulse interval, the microburst duration, or the interburst period is selected to enhance cranial nerve evoked potentials.
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20 Claims
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1. A method of treating a medical condition comprising:
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applying to a vagus nerve of the patient a pulsed electrical signal comprising a plurality of microbursts, wherein each microburst is characterized by; from 2 to 15 pulses per microburst; an interpulse interval between adjacent pulses of the microburst of from 1 to 20 milliseconds; and a microburst duration of not greater than 1 second; wherein each microburst is separated from an adjacent microburst by an interburst period of at least 100 milliseconds. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of treating a medical condition comprising:
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applying to a vagus nerve of the patient a pulsed electrical signal comprising a plurality of microbursts, wherein each microburst is characterized by; from 2 to 15 pulses per microburst; an interpulse interval between adjacent pulses of the microburst of from 1 to 20 milliseconds; and a microburst duration of not greater than 1 second; wherein at least one of the number of pulses per microburst, the interpulse interval, the microburst duration, or the interburst period is selected to enhance vagus nerve evoked potentials, and wherein each microburst is separated from an adjacent microburst by an interburst period comprising a time interval that is at least the length of one of the two microbursts separated by the interburst period.
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19. A method of treating a medical condition comprising:
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applying to a vagus nerve of the patient a pulsed electrical signal comprising a plurality of microbursts, wherein each microburst is characterized by; from 2 to 15 pulses per microburst; an interpulse interval between adjacent pulses of the microburst of from 1 to 20 milliseconds; and a microburst duration of not greater than 1 second; wherein at least one of the number of pulses per microburst, the interpulse interval, the microburst duration, or the interburst period is selected to enhance vagus nerve evoked potentials, and wherein each microburst is separated from an adjacent microburst by an interburst period comprising a time interval greater than that at which the enhanced vagus nerve evoked potentials significantly diminish or disappear.
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20. A method of treating a medical condition of a patient using an implantable medical device comprising applying a microburst electrical signal to a portion of a vagus nerve of said patient.
Specification