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Methods And Compositions For Base Calling Nucleic Acids

  • US 20100063743A1
  • Filed: 03/17/2009
  • Published: 03/11/2010
  • Est. Priority Date: 03/19/2008
  • Status: Active Grant
First Claim
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1. A method for determining an identity of a nucleic acid at an interrogation position in a nucleotide sequence from data acquired from one or more channels, comprisinga) obtaining a data set for one or more probe intensities at one or more nucleic acid positions in said sequence, wherein each probe corresponds to a nucleic acid,b) determining the ratio contribution to probe intensity at said interrogation position from probe intensities at the interrogation position and at one or both ofi) at least one subsequent nucleic acid positions in said sequence, andii) at least one preceding nucleic acid positions in said sequence, andc) applying said ratio contribution to probe intensity to said data set to arrive at an identity for a nucleic acid at said interrogation position in said nucleotide sequence.

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