MACROPOROUS AND HIGHLY RESORBABLE APATITIC CALCIUM-PHOSPHATE CEMENT

• US 20100068243A1
• Filed: 08/23/2007
• Published: 03/18/2010
• Est. Priority Date: 08/24/2006
• Status: Active Grant

• Current Assignee: Graftys Co., Universite De Nantes
• Original Assignee: Graftys Co., Universite De Nantes
• Inventors: Weiss, Pierre, Bouler, Jean-Michel, Khairoun, Ibrahim
• Granted Patent: US 9,642,939 B2
• Time in Patent Office: Days
• US Class Current: 424/426
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/0042 Materials resorbable by the body
• CPC Class Codes: A61L 24/0063 Phosphorus containing materials, e.g. apatite
• CPC Class Codes: A61L 24/0084 containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.

Claims

1. A cement powder useful as bone cement comprising an organic component consisting of one or more biocompatible and bioresorbable polymers, and an inorganic component consisting of one or more calcium phosphate compounds.

2. The cement powder according to claim 1, wherein said biocompatible and bioresorbable polymers are selected from the group consisting of polylactic acids, polyglycolic acids and poly(ε

)caprolactone and their associated copolymers, polyorthoester, polyanhydride, polydioxanone, hyaluronic acid and polyhydroxybutyrate, collagen, polyphosphazenes, dendrimers and polysaccharides, and their salts and mixtures thereof.

3. The cement powder according to claim 2, wherein said biocompatible and bioresorbable polymers are selected from the group consisting of polyphosphazenes, dendrimers, poly(ε

)caprolactone and polysaccharides, and their salts and mixtures thereof.

4. The cement powder according to claim 3, wherein said biocompatible and bioresorbable polymers are selected from the group consisting of polysaccharides and their salts.

5. The cement powder according to claim 4, wherein said polysaccharides are cellulose ethers.

6. The cement powder according to claim 5, wherein said cellulose ethers are selected from the group consisting of hydroxypropylmethylcellulose (HPMC) and carboxymethylcellulose (CMC).

7. The cement powder according to claim 3, wherein said biocompatible and bioresorbable polymers are polyphosphazenes selected from the group consisting of poly(ethyl oxybenzoate)phosphazene (PN-EOB), poly(propyl oxybenzoate) phosphazene (PN-POB), poly[bis(sodium carboxylatophenoxy)phosphazene] (Na-PCPP), poly[bis(potassium carboxylatophenoxy)phosphazene] (K-PCPP), poly[bis(ethyl alanato)phosphazene] (PAIaP), poly[bis(carboxylatophenoxy)phosphazene] (acid-PCPP), and their salts and mixtures thereof.

8. The cement powder according to claim 1, wherein said biocompatible and bioresorbable polymers are used as microparticles.

9. The cement powder according to claim 8, wherein said microparticles have a diameter between 20 and 300 μ

m.

10. The cement powder according to claim 8, wherein said microparticles are poly(ε

)caprolactone microspheres.

11. The cement powder according to claim 8, wherein said microparticles are microspheres or microcapsules, preferably encapsulating saccharose, glucose, water, a gas as air, an antibiotic, an anti-inflammatory drug, an anti-cancer drug, a drug against osteoporosis, a growth factor or a mixture thereof.

12. The cement powder according to claim 1, wherein said calcium phosphate compounds are selected from the group consisting of HA, ACP, MCPH, DCPD, DCPA, CDA, α

-TCP, β

-TCP, TTCP, and mixtures thereof.

13. The cement powder according to claim 12, wherein said calcium phosphate compounds are selected from the group consisting of α

-TCP, MCPH, DCPD and mixtures thereof.

14. The cement powder according to claim 1, wherein said calcium phosphate compounds comprise α

-TCP.

15. The cement powder according to claim 1, comprising at least about 70% of α

-TCP.

16. The cement powder according to claim 1, wherein the inorganic component consists of α

-TCP and DCPD.

17. The cement powder according to claim 1, wherein the amount of polymer is in the range from about 1 to about 5% of the powder total amount.

18. The cement powder according to claim 1, consisting of a mixture of α

-TCP, DCPD and HPMC.

19. An apatitic calcium phosphate cement resulting from the mixing of a powder cement according to claim 1 and a liquid phase, and setting.

20. The apatitic calcium phosphate cement according to claim 19, wherein the liquid phase is a NaCl solution, a Na₂HPO₄ aqueous solution or a Na₂HPO₄/NaH₂PO₄ aqueous solution.

21. The apatitic calcium phosphate cement according to claim 19, wherein the liquid phase/powder cement (L/S) ratio is between about 0.3 and about 0.6 ml/g.

22. The apatitic calcium phosphate cement according to claims 19, being injectable.

23. The apatitic calcium phosphate cement according to claim 19, comprising further one or more ingredients selected from the group of antibiotics, anti-inflammatory drugs, anti-cancer drugs, drugs against osteoporosis, growth factors.

24. A method for the treatment of a bony defect or a fracture caused by trauma or associated with osteoporosis, comprising the administration of a pharmaceutically acceptable amount of an injectable apatic calcium phosphate cement according to claim 19.

25. A scaffold for tissue engineering, comprising a CPC according to claim 19.

26. A method for the preparation of a dental or bony implant, comprising the use of a CPC according to claim 19.

27. Dental or bony implant consisting of a molding of a CPC according to claim 19.