Modifying a medicament availability state of a final dosage form
First Claim
Patent Images
1. An article of manufacture comprising:
- at least one final dosage form for administering a medicament to an animal, the final dosage form comprising;
the medicament; and
a particle or polymeric material carrying the medicament in a medicament-retention state wherein the medicament is substantially not bioavailable to the animal after administration of the final dosage form and modifiable ex vivo to a medicament-release state by an exposure to a stimulus wherein the medicament is substantially bioavailable to the animal after administration of the final dosage form; and
an instruction for the exposure of the particle or polymeric material ex vivo to a human-initiated stimulus sufficient to transform the particle or polymeric material to allow a discharge of at least a portion of the therapeutically effective amount of the medicament from the particle or polymeric carrier.
2 Assignments
0 Petitions
Accused Products
Abstract
Provided embodiments include a final dosage form, an article of manufacture, and method. A method of modifying a medicament availability state of a final dosage form is provided. The method includes initiating an exposure of a particle or polymeric material of the final dosage form to a stimulus. The initiated stimulus is selected to transform the particle or polymeric material from a medicament-retention state to a medicament-release state.
-
Citations
31 Claims
-
1. An article of manufacture comprising:
-
at least one final dosage form for administering a medicament to an animal, the final dosage form comprising; the medicament; and a particle or polymeric material carrying the medicament in a medicament-retention state wherein the medicament is substantially not bioavailable to the animal after administration of the final dosage form and modifiable ex vivo to a medicament-release state by an exposure to a stimulus wherein the medicament is substantially bioavailable to the animal after administration of the final dosage form; and an instruction for the exposure of the particle or polymeric material ex vivo to a human-initiated stimulus sufficient to transform the particle or polymeric material to allow a discharge of at least a portion of the therapeutically effective amount of the medicament from the particle or polymeric carrier. - View Dependent Claims (2, 3, 4, 5, 6)
-
-
7. A final dosage for administering a medicament to an animal, the final dosage form comprising:
-
at least one molecule of the medicament; and a particle or polymeric carrier bound with the at least one molecule of the medicament, configured in a first medicament-bioavailability state, and modifiable ex vivo to a second medicament-bioavailability state by an exposure to a stimulus. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
-
-
20. A method of modifying a medicament availability state of a final dosage form, wherein the final dosage form includes
the medicament; - and
a particle or polymeric material carrying the medicament in a medicament-retention state wherein the medicament is substantially not bioavailable if the final dosage form is administered to the animal, and transformable to the medicament-release state by the ex vivo exposure of the particle or polymeric material to a stimulus wherein the medicament is substantially bioavailable if the final dosage form is administered to the animal; and the method comprising; initiating an ex vivo exposure of the particle or polymeric material of the final dosage form to a stimulus, the initiated stimulus selected to transform the particle or polymeric material from a medicament-retention state to a medicament-release state. - View Dependent Claims (21, 22, 23, 24, 25, 26)
- and
-
27. A final dosage form for administering a medicament to an animal, the final dosage form comprising:
-
means for releasably engaging at least one molecule of the medicament; means for controlling an availability of the releasably engaged at least one molecule of medicament, wherein the releasably engaged at least one molecule of medicament is initially substantially not bioavailable if the final dosage form is administered to the animal, and wherein the availability of the releasably engaged medicament is modifiable ex vivo by an exposure to a stimulus to be substantially bioavailable if the final dosage form is administered to the animal; means for protecting the means for entrapping at least one molecule of the medicament from an ex vivo environment of the final dosage form; and the medicament. - View Dependent Claims (28, 29, 30, 31)
-
Specification