MICROFLUIDIC DEVICES
2 Assignments
0 Petitions
Accused Products
Abstract
Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such asDNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.
194 Citations
51 Claims
-
1-32. -32. (canceled)
-
33. A method comprising:
-
a) providing an instrument comprising; i) a microfluidic chip comprising a microfluidic channel; and ii) a device located off-chip and fluidically connected to the channel; b) in the device, contacting beads with a volume comprising an analyte, wherein the beads capture the analyte; and c) moving the beads with captured analyte into the microfluidic device through the fluidic connection, wherein the volume comprising the analyte is downscaled. - View Dependent Claims (34, 35, 36, 37, 38, 39)
-
-
40. An instrument comprising:
-
a) a microfluidic chip comprising a microfluidic channel fluidically connected to a port; and b) a reservoir located off-chip comprising capture beads and fluidically connected to the port. - View Dependent Claims (41)
-
-
42. A method comprising:
-
a) performing a reaction on at least one analyte in a microfluidic device to produce a reaction product; b) binding the reaction product to a bead; and c) purifying the bound reaction product. - View Dependent Claims (43, 44, 45, 46, 47)
-
-
48. A method comprising:
-
a) moving beads with attached analytes through a circuit of a microfluidic device; b) immobilizing the beads with attached analytes in a circuit of a microfluidic device using a magnetic field; c) eluting the analytes from the immobilized beads. - View Dependent Claims (49, 50, 51)
-
Specification