Tubular nanostructure targeted to cell membrane
2 Assignments
0 Petitions
Accused Products
Abstract
Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
-
Citations
162 Claims
-
1-94. -94. (canceled)
-
95. A method for providing a stable pore in a lipid bilayer membrane comprising:
- positioning across a lipid bilayer membrane a tubular nanostructure including a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in the lipid bilayer membrane and including at least one ligand configured to bind one or more cognates on the membrane.
- View Dependent Claims (96, 97, 98, 99, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140)
-
100-109. -109. (canceled)
-
110. A method for providing a stable pore in a lipid bilayer membrane comprising:
- positioning across a lipid bilayer membrane a composite tubular nanostructure including two or more nanotubes wherein at least one nanotube includes a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane.
- View Dependent Claims (111, 112, 113, 114, 115, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162)
-
116. A method for disrupting a lipid bilayer membrane of a cell comprising:
contacting the cell with at least one tubular nanostructure including a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in the lipid bilayer membrane and including at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cell. - View Dependent Claims (117, 118)
-
119. (canceled)
Specification