Lipids containing omega-3 and omega-6 fatty acids

• US 20100069332A1
• Filed: 11/16/2009
• Published: 03/18/2010
• Est. Priority Date: 10/22/2003
• Status: Active Grant

• Current Assignee: Enzymotec Limited (International Flavors & Fragrances Incorporated)
• Original Assignee: Enzymotec Limited (International Flavors & Fragrances Incorporated)
• Inventors: ZUABI, Rassan, FARKASH, Orly, PLATT, Dorit, BEN DROR, Gai, BAR-ON, Zohar, PELLED, Dori, SHULMAN, Avidor
• Granted Patent: US 8,470,345 B2
• Time in Patent Office: Days
• US Class Current: 514/77
• CPC Class Codes: A21D 2/32 Phosphatides
• CPC Class Codes: A23D 7/013 Spread compositions
• CPC Class Codes: A23D 9/013 Other fatty acid esters, e.g. phosphatides
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/322 having an effect on the health of the nervous system or on mental function
• CPC Class Codes: A23V 2250/1842 Lecithin
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/1942 Long-chain triglycerides
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A lipid preparation including a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidyl-inositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and/or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The preparation possesses an improved bioactivity, and is useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes.

Claims

1-25. -25. (canceled)

26. A method of treating a subject suffering from a disorder which is a concentration and attention disorder or a behavioral or learning problem which comprises administering to the subject a therapeutically effective amount of a preparation comprising a non-mammalian derived mixture of serine glycerophospholipid conjugates with each of EPA and DHA, wherein each glycerophospholipid conjugate has the formula (I):

wherein R″

is serine;

wherein each of R and R′

may be identical or different and may be hydrogen, acyl EPA or acyl DHA; and

wherein the amount of EPA and DHA present in the preparation constitutes 20-50% by weight of the total fatty acids content of said preparation.

27. The method according to claim 26, wherein the behavioral or learning problem is Attention Deficit Hyperactivity Disorder (ADHD).

28. The method according to claim 26, wherein said glycerophospholipid conjugate is prepared by enzymatic transphosphatidylation of a lipid source selected from the group consisting of plant, animal and microorganism sources.

29. The method according to claim 26, wherein the preparation is present in a pharmaceutical composition.

30. The method according to claim 29, wherein the pharmaceutical composition further comprises at least one pharmaceutically acceptable additive, diluent or excipient.

31. The method according to claim 30, wherein the pharmaceutical composition further comprises at least one additional pharmaceutically active agent.

32. The method according to claim 29, wherein the pharmaceutical composition is delivered orally or intravenously.

33. The method according to claim 26, wherein the preparation is present in a nutraceutical composition.

34. The method according to claim 33, wherein said nutraceutical composition is in the form of a softgel capsule, tablet, syrup, or other dietary supplement delivery system.

35. The method according to claim 26, wherein the preparation is present in a functional food.

36. The method according to claim 35, wherein the functional food is a dairy product, ice-cream, biscuit, soy product, bakery, pastry, bread, sauce, soup, prepared food, frozen food, condiment, confectionary, oil, fat, margarine, spread, filling, cereal, instant product, drink, shake, infant formula, infant food, bar, snack, candy or chocolate product.