Fluidic Medical Devices and Uses Thereof
First Claim
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1. An apparatus for detecting an analyte in a biological fluid of a subject, comprising:
- a) a sample collection unit for introducing a biological fluid in fluid communication with a plurality of reaction sites;
b) a plurality of reactant chambers carrying a plurality of reactants in fluid communication with said reaction sites,wherein said plurality of reaction sites comprise a plurality of reactants bound thereto for detecting said analyte; and
c) a system of fluidic channels to allow said biological fluid and said plurality of reactants to flow in said apparatus, wherein at least one channel located between said plurality of reaction sites comprises an optical barrier to reduce the amount of optical cross-talk between said plurality of said reaction sites during detection of said analyte.
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Abstract
This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.
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Citations
20 Claims
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1. An apparatus for detecting an analyte in a biological fluid of a subject, comprising:
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a) a sample collection unit for introducing a biological fluid in fluid communication with a plurality of reaction sites; b) a plurality of reactant chambers carrying a plurality of reactants in fluid communication with said reaction sites, wherein said plurality of reaction sites comprise a plurality of reactants bound thereto for detecting said analyte; and c) a system of fluidic channels to allow said biological fluid and said plurality of reactants to flow in said apparatus, wherein at least one channel located between said plurality of reaction sites comprises an optical barrier to reduce the amount of optical cross-talk between said plurality of said reaction sites during detection of said analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An apparatus for detecting an analyte in a biological fluid of a subject, comprising
a) a sample collection unit for introducing a biological fluid in fluid communication with a plurality of reaction sites, wherein said plurality of reaction sites comprise a plurality of bound reactants for detecting said analyte; -
b) a plurality of reactant chambers carrying a plurality of reactants in fluid communication with said reaction sites; and c) a system of fluidic channels to allow said biological fluid and said plurality of reactants to flow in said apparatus, wherein said bound reactants in at least one reaction site are unevenly distributed. - View Dependent Claims (13, 14, 15, 16)
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17. A method of manufacturing a fluidic device for detecting an analyte in a biological fluid of a subject, comprising:
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a) providing a plurality of layers of a fluidic device; b) ultrasonically welding said layers together such that a fluidic network exists between a sample collection unit, at least one reactant chamber, at least one reaction site, and at least one waste chamber. - View Dependent Claims (18, 19, 20)
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Specification