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Assays for Resistance to Echinocandin-Class Drugs

  • US 20100075302A1
  • Filed: 07/26/2006
  • Published: 03/25/2010
  • Est. Priority Date: 07/26/2005
  • Status: Active Grant
First Claim
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1. A nucleic acid assay for echinocandin drug resistance in fungi susceptible to echinocandin drugs and containing the FKS1 gene corresponding to 1-3β

  • -D-glucan synthase subunit Fks1p comprising amplifying a first nucleic acid target sequence of the FKS1 corresponding to at least a portion of CaFks1p amino acids 636 to 654 that includes amino acids 641 to 649, and detecting any difference from the wild-type allele in said amplified first target sequence.

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