Method And Glucose Monitoring System For Monitoring Individual Metabolic Response

• US 20100075353A1
• Filed: 09/17/2009
• Published: 03/25/2010
• Est. Priority Date: 03/23/2007
• Status: Abandoned Application

• Current Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Original Assignee: Disetronic Licensing Ag (Roche Holding AG)
• Inventors: Heaton, Kelly
• Application Number:
  US12/561,404
• Publication Number:
  US 20100075353A1
• Time in Patent Office: Days
• US Class Current: 435/14
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/6833 Adhesive patches
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: G16H 20/60 relating to nutrition control, e.g. diets
• CPC Class Codes: G16H 40/60 for the operation of medical equipment or devices

Abstract

A system and a method for monitoring individual metabolic responses and generating nutritional feedback based on the monitored responses in a qualified subject are disclosed. Measurements of glucose level in the subject are consecutively performed by a measuring device to generate corresponding first data. Subsequently, data is transmitted to an analysis device, where second data representing glycemic responses is generated from a time-series of glucose level measurements represented by the first data. In a next step, the second data is compared with a predetermined individual glycemic response budget for the subject which represents a total amount of individual glycemic responses allowable for a certain time period. Finally, feedback corresponding to the result of the comparison is provided by an output device.

Claims

1. A method for monitoring individual metabolic response and for generating nutritional feedback, involving monitoring of glycemic response in a qualified subject, comprising:

consecutively performing a plurality of measurements of a glucose level in the qualified subject by a measuring device;

in the measuring device generating first data corresponding to the measured glucose level;

transmitting the first data to an analysis device;

in the analysis device generating second data representing a glycemic response of the subject involving comparing a time-series of glucose measurements represented by the first data with a reference value for a fasting glucose level of the qualified subject;

comparing the second data with a predetermined individual glycemic response budget for the qualified subject, the individual glycemic response budget representing a total amount of individual glycemic response allowable for a certain time period; and

providing feedback corresponding to a result of the comparison on an output device.

2. The method as recited in claim 1, wherein generating second data comprises calculation of an area-under-the-curve (AUC) value.

3. The method as recited in claim 2, wherein comparing the second data comprises a comparison of the calculated area-under-the-curve (AUC) value corresponding to a predetermined time-interval to a reference AUC value corresponding to a recommended total carbohydrate intake during the predetermined time-interval.

4. The method as recited in claim 1, further comprising providing suggestions regarding how to achieve personal metabolic goals.

5. The method as recited in claim 1, wherein the measuring device is a continuous glucose monitoring device.

6. The method as recited in claim 1, wherein a transmission of the first data to the analysis device is activated depending on a value of the measured glucose level.

7. The method as recited in claim 1, wherein providing feedback on the output device involves user interaction in order to control interpretation of the second data.

8. The method as recited in claim 1, further comprising self-calibration for the measuring device which comprises establishing the reference value for the fasting glucose level of the qualified subject.

9. The method as recited in claim 8, wherein self-calibration is automatically and regularly effected during periods without ingestion of foods and glucose-affecting beverages by the subject.

10. The method as recited in claim 7, wherein self-calibration further comprises:

monitoring the subject'"'"'s glucose level during a minimum of six consecutive hours without ingestion of foods and beverages;

determining when glucose has stabilized at a fasting level; and

averaging a signal corresponding to a measured glucose concentration during an interval of greatest signal stability in order to determine the reference data corresponding to the fasting glucose level.

11. The method as recited in claim 1, further comprising correcting a raw signal corresponding to the measured glucose level against drift, signal instability or system error.

12. A glucose monitoring system for monitoring glycemic response in a qualified subject and for generating nutritional feedback, comprising:

a measuring device comprising a sensor for consecutively performing a plurality of measurements of a glucose level in the qualified subject and comprising a data generator for generating first data corresponding to the measured glucose level;

an analysis device comprising a computer to generate second data from the first data, the second data representing a glycemic response of the subject and the generation of the second data involving comparing a time-series of glucose measurements represented by the first data with a reference value for the fasting glucose level of the subject, and to compare the second data with a predetermined individual glycemic response budget for the qualified subject, the individual glycemic response budget representing a total amount of individual glycemic response allowable for a certain time period; and

a computer-controlled output device to provide feedback corresponding to a result of the comparison.

13. The system as recited in claim 12, wherein the measuring device is an implantable glucose sensor.

14. The system as recited in claim 13, wherein the measuring device comprises a storage for temporarily storing the first data and in that the measuring device and the analysis device comprise transmission components for off-loading of the accumulated stored first data to the analysis device after the measuring device has been removed from the body of the subject.

15. The system as recited in claim 12, wherein the measuring device and the analysis device comprise transmission components for transmitting the first data from the measuring device to the analysis device via a wireless link, and wherein the analysis device comprises a storage for storing the received first data.

16. The system as recited in claim 12, wherein the analysis device and the output device are comprised in a handheld device.

17. The system as recited in claim 12, wherein the analysis device comprises a storage for storing the predetermined individual glycemic response budget for the qualified subject.

18. The system as recited in claim 12, wherein at least one of the measuring device and the analysis device comprises at least one of a computer and an analog electronic circuit for performing at least one of filtering noise and correcting a raw signal corresponding to the measured glucose level against drift, signal instability or system error.

19. The system as recited in claim 12, wherein at least one of the analysis device and the output device comprises a user input device and in that it is designed and programmed in such a way that a user may control interpretation of the second data by using the input device.

20. The system as recited in claim 12, wherein the analysis device comprises a storage for storing second data as well as user-specified information.

21. A computer program product including program code which when executed on an analysis device carries out the following steps:

generating second data representing a glycemic response of a qualified subject from first data, involving comparing a time-series of glucose measurements in a qualified subject, represented by the first data, with a reference value for the fasting glucose level of the subject;

comparing the second data with a predetermined individual glycemic response budget for the qualified subject, the individual glycemic response budget representing a total amount of individual glycemic response allowable for a certain time period; and

generating at least one quantity relating to nutritional feedback based on the result of the comparison.