METHODS FOR CANCER THERAPY AND STEM CELL MODULATION
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Abstract
The present invention relates to a method of inducing apoptosis in a tumour cell as well as modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of general formula (I). In general formula A is C or N. R1, R4 and R5 are, independently selected, H or aliphatic, cycloaliphatic aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0-3 heteroatoms being N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen, such as F or Cl. R3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1-8 main chain carbon atoms and 0-3 heteroatoms being N, O, S, Si, or a halogen such as Cl or F. Also provided is a pharmaceutical composition for inducing apoptosis in a tumour cell and/or modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The pharmaceutical composition comprises a compound as defined above or a pharmaceutically acceptable salt thereof and a carrier or diluent.
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Citations
72 Claims
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1-23. -23. (canceled)
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24. A pharmaceutical composition, comprising
(a) a compound of formula (I) or a pharmaceutically acceptable salt thereof,
- 29. A method of inducing apoptosis in a tumour cell, said method comprising administering to said tumour cell a compound of the general formula (I)
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52-65. -65. (canceled)
- 66. A method for modulating gene expression in a cell that expresses the components of a polycomb repressive complex, said method comprising administering to said cell a compound of the general formula (I)
Specification