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Methods for Characterizing and Treating Cognitive Impairment In Aging and Disease

  • US 20100081648A1
  • Filed: 08/03/2006
  • Published: 04/01/2010
  • Est. Priority Date: 08/03/2005
  • Status: Active Grant
First Claim
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1. A method of identifying a gene or a plurality of genes associated with cognitive impairment in a mammal comprising the steps of:

  • (a) providing an AI population of aged mammals with cognitive impairment;

    (b) providing an AU population of aged mammals without cognitive impairment;

    (c) providing a Y population of young mammals;

    (d) determining the abundance of a plurality of expressed gene products in one or more of the CA1, CA3, and DG hippocampal tissue of each mammal in the AI, AU and Y populations; and

    (e) selecting a gene or a plurality of genes based on a significant increase or decrease in the relative abundance of the gene'"'"'s expressed gene product in the AI population of mammals relative to the combined AU and Y populations or in the AU population of mammals relative to the combined AI and Y populations.

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