LIGHT INTENSITY CONTROL FOR NEAR INFRARED SPECTROSCOPY

• US 20100084557A1
• Filed: 05/01/2008
• Published: 04/08/2010
• Est. Priority Date: 05/01/2007
• Status: Abandoned Application

• Current Assignee: Hegln (Dalian) Pharmaceuticals, Inc.
• Original Assignee: Urodynamix Technologies Ltd.
• Inventors: Koay, Phaik Sun, Zhu, Qichao, Li, Luya
• Application Number:
  US12/598,419
• Publication Number:
  US 20100084557A1
• Time in Patent Office: Days
• US Class Current: 250/339.70
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: G01J 3/108 for measurement in the infrared range
• CPC Class Codes: G01J 3/42 Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01N 21/255 Details, e.g. use of specially adapted sources, lighting or optical systems
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 2201/0612 Laser diodes
• CPC Class Codes: G01N 2201/0627 Use of several LED's for spectral resolution

Abstract

A system for near infrared spectroscopy includes a controller that automates selection of light intensities for one or more light sources. The system may stepwise increase or decrease a current driving a light source until a signal received at a light detector is within a desired range. The system may maintain closed loop control over the intensity of a light source after the intensity has been set. The closed loop control may be based on a signal from a second light detector that senses light from the light source. Current/intensity settings may be established for each of multiple light detectors. In response to selection of a light detector, the corresponding current may be delivered to drive the light source.

Claims

1. Apparatus for near infrared spectroscopy (NIRS) comprising:

a light source;

at least one first light detector positionable to detect light from the light source after the light has passed through tissues of a subject;

a controller connected to receive an output signal from the first light detector and configured to set an intensity of light emitted by the light source based at least in part on the output signal from the first light detector to cause the output signal from the first light detector to be in a predetermined range.

2. Apparatus according to claim 1 wherein the light source comprises a solid-state light source.

3. Apparatus according to claim 2 wherein the solid-state light source comprises a laser diode.

4. Apparatus according to claim 1 wherein the controller is configured to stepwise increase an electrical current drawn by the light source in response to determining that the output signal from the first light detector is below a lower threshold.

5. Apparatus according to claim 4 wherein the controller is configured to stepwise decrease an electrical current drawn by the light source in response to determining that the output signal from the first light detector is above an upper threshold.

6. Apparatus according to claim 4 wherein the controller is configured to set a step-size for the stepwise increase of electrical current based at least in part on a difference between the output signal from the first light detector and a desired output signal value.

7. Apparatus according to claim 5 wherein the controller is configured to set a step-size for the stepwise decrease of electrical current based at least in part on a difference between the output signal from the first light detector and a desired output signal value.

8. Apparatus according to claim 1 wherein the light source constitutes a first one of a plurality of light sources and the controller is configured to independently set the intensity for each one of the plurality of light sources.

9. Apparatus according to claim 8 wherein each of the plurality of light sources is capable of emitting light having spectral characteristics distinct from spectral characteristics of at least one other one of the plurality of light sources and the first light detector has different sensitivities to the light emitted by different ones of the light sources.

10. Apparatus according to claim 8 wherein the controller is configured to sequentially set the light output for each of the plurality of light sources.

11. Apparatus according to claim 8 wherein the controller is configured to:

operate light sources of the plurality of light sources in a plurality of different combinations;

determine a value for the output signal from the first light detector corresponding to each one of the different combinations; and

, set the intensity of the first one of a plurality of light sources based upon the values for the output signal corresponding to a plurality of the combinations.

12. Apparatus according to claim 8 comprising a control configured to regulate current drawn by each of the plurality of light sources to have a value corresponding to the intensity set by the controller for the light source.

13. Apparatus according to claim 12 wherein the control comprises a closed-loop control.

14. Apparatus according to claim 13 comprising one or more second light detectors positioned to receive light emitted by light sources of the plurality of light sources wherein the closed-loop control controls the current drawn by each of the plurality of light sources in response to a signal from the second light detectors.

15. Apparatus according to claim 1 wherein the controller is configured to generate an alarm indication in the event that the controller fails to cause the output signal from the first light detector to be in a predetermined range after a predetermined number of attempts.

16. Apparatus according to claim 1 comprising a second light detector located to detect light emitted by the light source.

17. Apparatus according to claim 16 comprising a closed-loop control set to control a light output of the light source to have the intensity set by the controller in response to a signal from the second light detector.

18. Apparatus according to claim 1 wherein the controller comprises a programmed data processor.

19. Apparatus according to claim 1 comprising a plurality of first light detectors wherein the controller is configured to determine and store information specifying a set light intensity for the light source corresponding to each of the plurality of first light detectors.

20. An automated method for set up of apparatus for near infrared spectroscopy (NIRS) comprising a solid-state light source and a first light detector positionable to detect light from the light source after the light has passed through tissues of a subject, the method comprising the steps of:

(a) setting a current drawn by the solid-state light source to an initial value;

(b) comparing an output signal of the light detector to a desired range;

(c) if the output signal is outside of the desired range stepwise increasing or decreasing the current to cause the light output to approach the desired range; and

,

(d) repeating steps (b) and (c) until the output signal is within the desired range or a termination condition is satisfied.

21. A method according to claim 20 comprising repeating the method for each one of a plurality of different solid-state light sources.

22. A method according to claim 20 comprising setting a step size for step (c) based at least in part upon a difference between the output signal and a desired value for the output signal.

23. A method according claim 20 wherein the first light detector constitutes one of a plurality of first light detectors wherein the method comprises repeating the method for each one of the plurality of first light detectors.

24. A method according to claim 23 comprising, for at least one of the plurality of first light detectors storing information specifying a current for the first light source.

25. A method according to claim 24 comprising, upon selection of the one of the plurality of first light detectors, retrieving the information specifying a current for the first light source and controlling the current to the first light source according to the specified current.

26. A method according to claim 20 comprising operating the light source while maintaining closed loop control of current to the light source.

27. A method according to claim 26 wherein maintaining closed loop control of current to the light source comprises monitoring an intensity of light output by the solid-state light source by way of a second light sensor and controlling the current to the solid-state light source based on an output from the second light sensor.

28-29. -29. (canceled)