Determining Age Ranges of Skin Samples
First Claim
1. A method for determining the age range of a skin sample of a subject comprising analyzing nucleic acid from one or more genes listed in Table 1, Table 2, Table 3, or any combination thereof, in a sample of the skin from the subject, thereby determining the age range of the skin of the subject.
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Abstract
The present invention provides methods for characterizing a skin sample of a subject as belonging to an age range by analyzing nucleic acid or protein molecules obtained from the subject. The methods include analyzing expression or mutations in epidermal samples, of one or more skin markers. The methods can include the use of a microarray to analyze gene or protein profiles from a sample and compare them with a known skin age index. Therapeutic and cosmetic formulations are also provided herein.
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Citations
38 Claims
- 1. A method for determining the age range of a skin sample of a subject comprising analyzing nucleic acid from one or more genes listed in Table 1, Table 2, Table 3, or any combination thereof, in a sample of the skin from the subject, thereby determining the age range of the skin of the subject.
- 16. A method of identifying an age range for a skin sample comprising analyzing a nucleic acid from the sample as compared with one or more genes listed in Table 1, Table 2, Table 3, or any combination thereof, and identifying the age range of the skin based on the analysis.
- 23. A method for determining the age range of skin of a subject comprising detecting an altered level of a target protein in a sample from the subject, as compared to the level of the target protein in a corresponding sample from a subject of known age range, wherein the protein is an expression product of a gene listed in Table 1, Table 2, Table 3, or any combination thereof, thereby determining the age range of the subject.
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26. A method for determining the age range of skin of a subject comprising:
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a) providing a gene expression profile of a target area of the skin of the subject, wherein the target area of the skin simultaneously expresses a plurality of genes at the protein level that are markers for a specific age range; and b) comparing the subject'"'"'s gene expression profile to a reference gene expression profile obtained from a corresponding skin sample of known age range, wherein the reference gene expression profile comprises an expression value of one or more target genes listed in Table 1, Table 2, Table 3, or any combination thereof. - View Dependent Claims (27, 28)
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- 29. A kit for determining the age range of skin in a subject comprising an applicator and one or more probes or primers that selectively bind to one or more of nucleic acid molecules in Table 1, Table 2, Table 3, or any combination thereof, or to a nucleic acid or protein expression product of a nucleic acid molecule in any of Table 1, Table 2, Table 3, or any combination thereof.
- 34. A cosmetic formulation containing agents for reducing or increasing expression of genes in Table 1, Table 2, Table 3, or any combination thereof.
Specification