Contact Lens Care Solutions with a Low Molecular Weight Oligomer

• US 20100086514A1
• Filed: 10/01/2009
• Published: 04/08/2010
• Est. Priority Date: 10/01/2009
• Status: Abandoned Application

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Heiler, David J., Liu, X. Michael
• Application Number:
  US12/571,465
• Publication Number:
  US 20100086514A1
• Time in Patent Office: Days
• US Class Current: 424/78.80
• CPC Class Codes: A01N 25/00 Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application , e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A61L 12/142 Polymeric biguanides
• CPC Class Codes: A61L 12/145 Polymeric quaternary ammonium compounds

Abstract

A contact lens care solution comprising: a cationic antimicrobial component having an average molecular weight (M_NA), and a cationic oligomer or nitrogen/amine oligomer having a number average molecular weight (M_NO) from 500 daltons to 15,000 daltons. The lens care solutions are used to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

Claims

1. A contact lens care solution comprising:

a cationic antimicrobial component having an average molecular weight (M_NA); and

a cationic oligomer or nitrogen/amine oligomer having a number average molecular weight (M_NO) from 500 daltons to 15,000 daltons, wherein the wherein the cationic oligomer or nitrogen/amine oligomer is present in the composition from 0.01 wt. % to 1.0 wt. %, and the composition comprises a ratio M_NO;

M_NA from 5;

1 to 1;

5.

2. The lens care solution of claim 1, wherein the ratio M_NO:

M_NA is from 3;

1 to 1;

3.

3. The lens care solution of claim 1, wherein the cationic antimicrobial component is poly(hexamethylene biguanide), which is present in the composition from 0.3 ppm to 2 ppm, or polyquaternium-1, which is present in the composition from 0.5 ppm to 15 ppm.

4. The lens care solution of claim 1, further comprising a comfort agent selected from the group consisting of dexpanthenol, hydroxypropyl guar, hyaluronic acid, hydroxypropylmethyl cellulose and the corresponding metal salts of each thereof.

5. The lens care solution of claim 4, wherein the comfort agent is hyaluronic acid.

6. The lens care solution of claim 1, wherein the cationic oligomer or nitrogen/amine oligomer is selected from the group consisting of polyvinylpyridine, polyvinylpyrrolidone, polyethyleneimine and a copolymer comprising polyvinylpyridine, polyvinylpyrrolidone or polyethyleneimine.

7. The lens care solution of claim 1, wherein the number average molecular weight of the cationic oligomer or nitrogen/amine oligomer is from 1500 daltons to 6000 daltons.

8. The lens care solution of claim 6, wherein the number average molecular weight of the cationic oligomer or nitrogen/amine oligomer is from 1500 daltons to 6000 daltons.

9. The lens care solution of claim 6, wherein the cationic antimicrobial component is poly(hexamethylene biguanide) and is present in the solution from 0.1 ppm to 2.0 ppm, and the hyaluronic acid and is present in the composition from 0.005 wt. % to 0.04 wt. %.

10. A method of cleaning and disinfecting a contact lens, the method comprising instructing a person who uses contact lenses to soak the contact lens in the composition of claim 1 for at least 2 hours.

11. The method of claim 10, further comprising instructing the person to place the soaked contact lens on the eye without the need to rinse the soaked lens prior to placement on the eye.

12. A contact lens care solution comprising:

a cationic antimicrobial component having an average molecular weight (M_NA); and

0.01 wt. % to 1.0 wt. % polyvinylpyrrolidone oligomer having a number average molecular weight (M_NO) from 500 daltons to 5,000 daltons, and the composition comprises a ratio M_NO;

M_NA from 5;

1 to 1;

5.

13. The lens care solution of claim 12, wherein the ratio M_NO:

M_NA is from 3;

1 to 1;

3.

14. The lens care solution of claim 12, wherein the cationic antimicrobial component is poly(hexamethylene biguanide), which is present in the composition from 0.3 ppm to 2 ppm, polyquaternium-1, which is present in the composition from 0.5 ppm to 15 ppm, or polyquaternium-42, which is present in the composition from 5 ppm to 60 ppm.