TOPICAL TREATMENT OF SKIN INFECTION

• US 20100087403A1
• Filed: 10/03/2008
• Published: 04/08/2010
• Est. Priority Date: 10/03/2008
• Status: Active Grant

• Current Assignee: Winlind Skincare LLC
• Original Assignee: Winlind Skincare LLC
• Inventors: CHIOU, WIN L.
• Granted Patent: US 8,846,646 B2
• Time in Patent Office: Days
• US Class Current: 514/164
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/10 Anti-acne agents

Abstract

The invention relates to an unexpected discovery that propylene glycol is highly effective at killing or inhibiting Propionibacterium acnes in a mammalian skin disorder, as well as to the use of propylene glycol and salicylic acid in a skin-disorder treatment. This invention also relates to compositions containing propylene glycol alone or in combination with salicylic acid for use in killing or inhibiting Propionibacterium acnes.

Claims

1. A method for killing and/or inhibiting Propionibacterium acnes in a mammalian skin disorder comprising topically applying a therapeutically effective amount of propylene glycol alone or in combination with a therapeutically effective amount of salicylic acid in a pharmaceutically acceptable dosage form to the area of skin disorder.

2. The method of claim 1 wherein the skin disorder is acne and the concentrations of propylene glycol and salicylic acid range from about 5% to about 100% by weight and from about 0.05% to about 6% by weight, respectively.

7. The method of any of claims 1, 3-5, 10, and 11 wherein the concentration of propylene glycol ranges from about 10% to about 100% by weight.

8. The method of any of claims 1, 3-5, 10, and 11 wherein the concentration of propylene glycol ranges from about 20% to about 100% by weight.

9. The method of any of claims 1, 3-5, 10, and 11 wherein the concentration of propylene glycol ranges from about 50% to about 100% by weight.

3. A method of treating acne comprising topically applying a therapeutically effective amount of propylene glycol in a pharmaceutically acceptable dosage form to the area of lesion of the acne.

4. A method of treating acne comprising topically applying a therapeutically effective amount of propylene glycol in combination with salicylic acid in a pharmaceutically acceptable dosage form to the area of lesion of the acne.

6. The method of claims 4-5 wherein the concentrations of propylene glycol and salicylic acid range from about 5% to about 100% by weight and from about 0.05% to about 6% by weight, respectively.

5. A method of treating rosacea comprising topically applying a therapeutically effective amount of propylene glycol alone or in combination with salicylic acid in a pharmaceutically acceptable dosage form to the area of lesion of the rosacea.

10. A method of treating acne comprising topically applying a therapeutically effective amount of propylene glycol in a pharmaceutically acceptable dosage form to the area of lesion of the acne.

11. A method of treating rosacea comprising topically applying a therapeutically effective amount of propylene glycol in a pharmaceutically acceptable dosage form to the area of lesion of the rosacea.