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Compositions and Methods for Inhibiting Expression of Eg5 and VEGF Genes

  • US 20100087508A1
  • Filed: 09/01/2009
  • Published: 04/08/2010
  • Est. Priority Date: 03/05/2008
  • Status: Abandoned Application
First Claim
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1. A composition comprising a first double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a human kinesin family member 11 (Eg5/KSP) gene in a cell and a second dsRNA for inhibiting expression of a human VEGF in a cell, wherein:

  • both said first and said second dsRNA are formulated in a stable nucleic acid lipid particle (SNALP);

    said first dsRNA consists of a first sense strand and a first antisense strand, and said first sense strand comprises a first sequence and said first antisense strand comprises a second sequence complementary to at least 15 contiguous nucleotides of SEQ ID NO;

    1311 (5′

    -UCGAGAAUCUAAACUAACU-3′

    ), wherein said first sequence is complementary to said second sequence and wherein said first dsRNA is between 15 and 30 base pairs in length; and

    said second dsRNA consists of a second sense strand and a second antisense strand, said second sense strand comprising a third sequence and said second antisense strand comprising a fourth sequence complementary to at least 15 contiguous nucleotides of SEQ ID NO;

    1538 (5′

    -GCACAUAGGAGAGAUGAGCUU-3′

    ), wherein said third sequence is complementary to said fourth sequence and wherein each strand is between 15 and 30 base pairs in length.

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