USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES
0 Assignments
0 Petitions
Accused Products
Abstract
Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol'"'"'s biological properties. The significance of equol'"'"'s ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT'"'"'s biological actions in physiological and pathophysiological processes.
-
Citations
39 Claims
-
1-22. -22. (canceled)
-
23. A method of modulating androgen hormone action so as to ameliorate at least one condition of the prostate in a subject, comprising
administering equol comprising a non-racemic mixture of R-equol and S-equol enantiomers to the subject.
-
28. A method of ameliorating at least one condition of the prostate in a subject, comprising
administering equol comprising a non-racemic mixture of R-equol and S-equol enantiomers.
- 33. A method of ameliorating benign prostatic hyperplasia in a subject, comprising administering equol comprising a non-racemic mixture of R-equol and S-equol enantiomers.
- 36. A method of co-modulating androgen hormone actions and estrogen hormone action so as to ameliorate benign prostatic hyperplasia in a subject, comprising administering equol comprising a non-racemic mixture of R-equol and S-equol enantiomers.
-
39. A pharmaceutical composition for ameliorating benign prostatic hyperplasia in a subject comprising
equol comprising a non-racemic mixture of R-equol and S-equol enantiomers; - and
at least one of a pharmaceutically acceptable carrier, adjuvant, or excipient.
- and
Specification