METHOD OF CHARACTERIZATION AND DIFFERENTIATION OF TISSUE
First Claim
1. A method of soft tissue characterization and differentiation comprising the steps of:
- (a) detecting a lesion and its location in said tissue;
(b) collecting a sequence of stress patterns as a function of an increasing compression force when said tissue is compressed over said location;
(c) calculating from said sequence at least three elasticity features characterizing said lesion, said elasticity features selected from a group consisting of strain hardening, loading curve average slope, lesion peak signal under a predetermined load, tissue heterogeneity, lesion shape and lesion mobility;
(d) comparing said at least three calculated elasticity features using a statistical classifier against a dataset of previously collected samples with known clinical status, said samples including data on same calculated elasticity features, and(e) providing a diagnosis of said soft tissue based on that comparison.
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Abstract
A novel method for soft tissue characterization includes obtaining a sequence of surface stress patterns as a function of an increasing compression force when a probe is pressed against the tissue over the location of the lesion of interest. A number of elasticity features are then calculated to characterize the tissue and the lesion located therein including strain hardening, loading curve average slope, lesion peak signal under a predetermined load, tissue heterogeneity, lesion shape and lesion mobility. At least three elasticity features are provided as an input to a statistical Bayesian classifier trained on a clinical database to calculate the probability of the lesion being benign or malignant. Additional patient-related parameters may be further provided as inputs to the classifier to increase the accuracy of differentiation between benign and malignant lesions. These parameters include a family history of cancer disease, a patient-inherited genetic factor, a history of said tissue related diseases, patient'"'"'s age, patient'"'"'s weight, and patient'"'"'s lifestyle and dietary factors. The method of the invention along with other non-invasive examinations of lesions may help in reducing the rate of biopsies, specifically breast tissue biopsies.
36 Citations
10 Claims
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1. A method of soft tissue characterization and differentiation comprising the steps of:
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(a) detecting a lesion and its location in said tissue; (b) collecting a sequence of stress patterns as a function of an increasing compression force when said tissue is compressed over said location; (c) calculating from said sequence at least three elasticity features characterizing said lesion, said elasticity features selected from a group consisting of strain hardening, loading curve average slope, lesion peak signal under a predetermined load, tissue heterogeneity, lesion shape and lesion mobility; (d) comparing said at least three calculated elasticity features using a statistical classifier against a dataset of previously collected samples with known clinical status, said samples including data on same calculated elasticity features, and (e) providing a diagnosis of said soft tissue based on that comparison. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification