COMPOSITIONS AND METHODS FOR USE OF ALGINATE DURAL SEALANTS

• US 20100087853A1
• Filed: 06/08/2009
• Published: 04/08/2010
• Est. Priority Date: 03/10/2003
• Status: Abandoned Application

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Vetter, Rio J., Kipke, Daryl A., Becker, Timothy A., Williams, Justin C.
• Application Number:
  US12/480,133
• Publication Number:
  US 20100087853A1
• Time in Patent Office: Days
• US Class Current: 606/213
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/08 Polysaccharides A61L24/043 takes precedence
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: C08L 5/04 Alginic acid; Derivatives thereof

Abstract

The present invention comprises compositions and methods for use of an alginate dural sealant in conjunction with mammalian neurosurgical procedures, including but not limited to, the implantation of neuroprosthetic devices.

Claims

1-16. -16. (canceled)

17. A method of sealing the site of a neurosurgical procedure comprising:

applying a purified alginate solution to the site of a neurosurgical procedure in a mammal, and

adding a calcium chloride solution to form a polymer,

wherein the purified alginate solution has a G/M ratio greater than 60/40.