METHOD AND APPARATUS FOR TREATING APNEA/HYPOPNEA

• US 20100089396A1
• Filed: 09/06/2007
• Published: 04/15/2010
• Est. Priority Date: 09/08/2006
• Status: Active Grant

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Mulcahy, David, Kwok, Philip Rodney, Farrugia, Steven Paul, Richard, Ron
• Granted Patent: US 8,616,206 B2
• Time in Patent Office: Days
• US Class Current: 128/204.230
• CPC Class Codes: A61B 5/0826 Detecting or evaluating apnoea events A61B5/4818 takes precedence
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 2016/0027 pressure meter

Abstract

Methods and/or apparatuses for treating sleep-disordered breathing (SDB) are provided. In particular, systems and/or methods are provided which may temporarily boost the pressure of a supply of breathable gas provided by an AutoSet device for the treatment of hypopnea. In certain example embodiments, a supply of breathable is provided to patients to treat apneas and/or hypopneas. The presence and/or absence of apneas and/or hypopneas are detected (e.g. by monitoring the Apnea-Hypopnea Index). When hypopnea events are detected, the pressure of the supply of breathable gas temporarily is increased above the Pcrit and/or CPAP levels, at least during patient inspiration. When the hypopnea events are normalized, the pressure is reduced. In certain example embodiments, the pressure will not be increased when a non-hypopnea event is detected at the same time as a hypopnea event.

Claims

1. A method of treating a patient with sleep-disordered breathing, the method comprising:

providing a supply of pressurized breathable gas at a treatment pressure, the treatment pressure being substantially constant during patient inspiration and patient expiration;

generating a first signal when a hypopnea event is detected;

increasing the pressure of the supply of pressurized breathable gas to a boosted pressure during patient inspiration in response to the first signal to normalize the hypopnea event; and

,

when the hypopnea event is normalized, providing the supply of pressurized breathable gas to the patient at the substantially constant treatment pressure.

2. The method of claim 1, further comprising:

generating a second signal when an obstructive event is detected; and

,

adjusting the substantially constant treatment pressure in response to the second signal.

3. The method of claim 2, wherein the pressure of the supply of pressurized breathable gas is increased to the boosted pressure only when an obstructive event is not detected.

4. The method of any one of claim 1, wherein the boosted pressure is a pressure above a predetermined threshold pressure.

5. The method of claim 4, wherein the threshold pressure is Pcrit.

6. The method of claim 4, wherein the threshold pressure is the treatment pressure.

7. The method of any one of claim 4, wherein the boosted pressure is approximately 1-3 cm H₂O above the threshold pressure.

8. The method of any one of claim 1, wherein the hypopnea event and/or the hypopnea normalization is detected based at least in part on AHI.

9. The method of any one of claim 1, wherein the supply of pressurized breathable gas is provided by a CPAP device.

10. The method of any one of claim 1, wherein the supply of pressurized breathable gas is provided by a device configured to monitor at least one parameter of the patient and provide the pressure of the breathable gas based on the at least one parameter.

11. The method of any one of claim 1, wherein the pressure of the breathable gas is in the range of approximately 3-20 cm H₂O.

12. The method of any one of claim 1, wherein the boosted pressure is less than approximately 3 cm H₂O above a predetermined threshold level.

13. The method of claim 12, wherein the threshold level is a Pcrit level associated with the patient.

14. A method of treating a patient with sleep-disordered breathing, the method comprising:

providing a supply of pressurized breathable gas at a selectable treatment pressure according to a first treatment mode, wherein the first treatment mode provides a constant treatment pressure during patient inspiration and patient expiration;

generating a first signal when an obstructive event is detected;

adjusting the treatment pressure of the supply of pressurized breathable gas to treat the patient for the obstructive event in response to the first signal;

generating a second signal when a hypopnea event is detected;

providing a supply of pressurized breathable gas according to a second treatment mode to normalize the hypopnea in response to the second signal, wherein the second treatment mode provides an increased pressure during patient inspiration compared to the pressure provided during patient expiration; and

,

when the hypopnea event is normalized, providing a supply of pressurized breathable gas according to the first treatment mode.

15. The method of claim 14, wherein the pressure provided during patient expiration in the second treatment mode is the same as the treatment pressure provided during the first treatment mode.

16. The method of claim 14, wherein the supply of pressurized gas is provided according to the second treatment mode only when an obstructive event is not detected.

17. A system for delivering therapeutic treatment pressure to a patient suffering from sleep-disordered breathing, comprising:

a controllable flow generator operable to generate a supply of pressurized breathable gas to be delivered to the patient at a treatment pressure, the treatment pressure being substantially constant during patient inspiration and patient expiration;

a sensor operable to generate a signal related to the presence and/or absence of a hypopnea event;

a processor operable to control the controllable flow generator, and further operable to determine whether a hypopnea event is occurring based at least in part on the signal; and

,

a pressure boost circuit responsive to the signal operable to instruct the controllable flow generator to increase pressure of the supply of pressurized breathable gas to a boosted pressure during patient inspiration when the signal corresponds to the occurrence of a hypopnea event until the hypopnea event is normalized.

18. The system of claim 17, wherein the sensor is further operable to generate a second signal related to the presence and/or absence of an obstructive event, and

wherein the processor is further operable to adjust the substantially constant treatment pressure based on a determination as to whether an obstructive event is occurring, the determination as to whether an obstructive event is occurring being based at least in part on the second signal.

19. The system of claim 18, wherein the pressure boost circuit instructs the controllable flow generator to increase the pressure of the supply of pressurized breathable gas when a hypopnea is occurring and no obstructive event is occurring.

20. The system of any one of claim 17, wherein the boosted pressure is a pressure above a predetermined threshold pressure.

21. The system of claim 20, wherein the threshold pressure is Pcrit.

22. The system of claim 20, wherein the threshold pressure is the treatment pressure.

23. The system of any one of claim 20, wherein the boosted pressure is approximately 1-3 cm H₂O above the threshold pressure.

24. The system of any one of claim 20, wherein the hypopnea event and/or the hypopnea event normalization is detected based at least in part on AHI.

25. The system of any one of claim 20, wherein the flow generator is a CPAP device.

26. The system of any one of claim 20, wherein the treatment pressure is in the range of approximately 3-20 cm H₂O.

27. The system of any one of claim 20, wherein the boosted pressure is less than approximately 3 cm H₂O above a predetermined threshold level.

28. The system of claim 27, wherein the predetermined threshold level is a Pcrit level associated with the patient.

29. A system for delivering therapeutic treatment pressure to a patient suffering from sleep-disordered breathing, comprising:

a controllable flow generator operable to generate a supply of pressurized breathable gas to be delivered to the patient at a treatment pressure, the treatment pressure being substantially constant during patient inspiration and patient expiration;

a sensor operable to generate a first signal related to the presence and/or absence of a hypopnea event and a second signal related to the presence and/or absence of an obstructive event;

a processor operable to control the controllable flow generator, and further operable to determine whether a hypopnea event is occurring based at least in part on the first signal and to determine whether an obstructive event is occurring based at least in part on the second signal; and

,

a pressure boost circuit responsive to the first signal operable to instruct the controllable flow generator to increase pressure of the supply of pressurized breathable gas to a boosted pressure during patient inspiration when the first signal corresponds to the occurrence of a hypopnea event until the hypopnea event is normalized.

30. The system of claim 29, wherein the pressure boost circuit instructs the controllable flow generator to increase the pressure of the supply of pressurized breathable gas when a hypopnea is occurring and no obstructive event is occurring.

31. A PAP device for treating a patient suffering from sleep-disordered breathing, comprising:

a controllable flow generator operable to generate a supply of pressurized breathable gas to be delivered to the patient; and

,

a processor configured to operate in a first mode for treating an obstructive event, and further configured to operate in a second mode for treating a non-obstructive event;

wherein the first mode includes causing the controllable flow generator to provide the supply of pressurized breathable gas at a first treatment pressure, and

wherein the second mode includes causing the controllable flow generator to provide the supply of pressurized breathable gas at a second treatment pressure until the non-obstructive event is normalized, the second treatment pressure at least during patient inspiration being higher than the first treatment pressure.

32. The PAP device of claim 31, wherein the second treatment pressure is a pressure above Pcrit.

33. The PAP device of claim 32, wherein the second treatment pressure is approximately 1-3 cm H₂O above Pcrit.

34. The PAP device of any one of claim 31, wherein the processor operates in the second mode only when the processor is not operating in the first mode.

35. The PAP device of any one of claim 31, wherein the processor is operable to switch between the first and mode the second mode in response to an AHI of the patient.

36. The PAP device of any one of claim 31, wherein the flow generator is a CPAP device.

37. The PAP device of claim 36, wherein the first treatment pressure is substantially constant during patient inspiration and patient expiration at least when the processor operates in the first mode.

38. The PAP device of any one of claim 31, wherein the pressure of the breathable gas is in the range of approximately 3-20 cm H₂O.

39. The PAP device of any one of claim 31, wherein the second treatment pressure is less than approximately 3 cm H₂O above a predetermined threshold level.

40. The PAP device of any one of claim 31, wherein the threshold level is a Pcrit level associated with the patient.

41. The PAP device of any one of claim 31, wherein the flow generator is a bilevel device.

42. The PAP device of claim 41, wherein the flow generator is operable to provide the supply of pressurized breathable gas at a first inhalation pressure during patient inhalation and a second expiration pressure during patient expiration when the processor operates in the first mode, the first pressure being different from the second pressure.

43. The PAP device of claim 42, wherein the flow generator is operable to increase the first pressure and/or the second pressure when the processor operates in the second mode.