System and process for recording ERG, PERG and VEP multifocal electrofunctional responses in real-time

• US 20100091242A1
• Filed: 04/18/2009
• Published: 04/15/2010
• Est. Priority Date: 04/18/2008
• Status: Active Grant

• Current Assignee: Costruzioni Strumenti Oftalmici C.S.O. S.R.L.
• Original Assignee: Contruzioni Strumenti Oftalmici SRL
• Inventors: Vestri, Gabriele, Versaci, Francesco, Baglini, Claudio
• Granted Patent: US 8,220,928 B2
• Time in Patent Office: Days
• US Class Current: 351/205
• CPC Class Codes: A61B 3/12 for looking at the eye fundus, e.g. ophthalmoscopes A61B3/13 takes precedence
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/398 Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
• CPC Class Codes: A61B 5/7228 Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal modulation H03C

Abstract

Process and system for determining the topography of bioelectric response signals of a visual system including a patient'"'"'s retina, optical nerve or a projection thereof at the level of the central cortex, following visual stimulation through a surface arranged in front of the patient'"'"'s eye. An image which comprises a plurality of cells is displayed as stimulation, each cell being activated or deactivated according to a corresponding digital time function represented by a cyclical succession of binary m-sequences of duration (T) formed from a plurality of activation symbols (N), each having a duration (Ts), the m-sequences of the various cells being obtained cyclically from a mother m-sequence. The process determines the total bioelectric response of the visual system, the response associated with each cell being determined by the total response of the visual system using a cross-correlation with a suitable translated version of a mother m-sequence. The calculation of the response of each cell is updated at the end of each symbol time (Ts), thereby making it possible to follow the evolution of the calculated response of each cell in real-time, without awaiting the end of an m-sequence.

Claims

1. A process for determining the topography of bioelectric response signals of a visual system of a patient, the patient'"'"'s retina, optical nerve or a projection thereof being at the level of the central cortex, following visual stimulation through a surface arranged in front of the patient'"'"'s eye, wherein an image which comprises a plurality of cells is displayed as stimulation, each cell being activated or deactivated according to a corresponding digital time function represented by a cyclical succession of binary m-sequences of duration (T) formed by a plurality of activation symbols (N), each having a duration (Ts), the m-sequences of the various cells being obtained cyclically from a mother m-sequence, the process determining the total bioelectric response of the visual system, the response associated with each cell being determined by the total response of the visual system using a cross-correlation with a suitable translated version of a mother m-sequence, wherein calculation of the response of each cell is updated at the end of each symbol time (Ts), thereby making it possible to follow the evolution of the calculated response of each cell in real time, without awaiting the end of an m-sequence.

2. The process set forth in claim 1, wherein updating is accomplished, after a certain number (k) of symbol times (Ts) to obtain the response of a q-th cell associated with an m-sequence translated by a number (q) of symbols from the mother m-sequence, by cross-correlating the data extracted from the overall response not with the translated m-sequence, but with a version thereof cyclically delayed by the number (k) to obtain the current response of the q-th cell due to a number (N) of most recent stimuli.

3. The process set forth in claim 1, wherein calculated wave-forms associated with the various cells are either directly interpreted or are associated with a pattern comprising luminous, isoluminant or gray-scale chromatic stimuli that mirrors the matrix of the stimuli.

4. The process set forth in claim 1, wherein the accuracy of the acquisition step is evaluated based on an intrinsic coefficient of variation (CV) and a standard error of the mean (SEM) of the result obtained in real-time.

5. The process set forth in claim 4, wherein the intrinsic coefficient of variation (CV) and the standard error of the mean (SEM) are calculated in accordance with

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6. The process set forth in claim 1, wherein the result obtained by the patient examined is compared with a normative database that includes results obtained on normal subjects, to indicate the deviation of the subject compared to the average of the normal subjects in relation to age.

7. A system for determining the topography of bioelectric response signals of a visual system of a patient including the patient'"'"'s retina, optical nerve or a projection thereof at the level of the central cortex, following visual stimulation, the system comprising a display arranged in front of the patient'"'"'s eye, a processor connected to the display for showing an image, as stimulation, including a plurality of cells, each cell being activated or deactivated according to a corresponding digital time function represented by a cyclical succession of binary m-sequences of duration (T) formed by a plurality of activation symbols (N), each having a duration (Ts), the m-sequences of the various cells being obtained cyclically from a mother m-sequence, the system further comprising a sensor and amplifier for determining the total bioelectric response of the visual system, and recording the response on the processor, such that the response associated with each cell is determined by the total response of the visual system using a cross-correlation with a suitable translated version of a mother m-sequence, wherein processor updates the calculation of the response of each cell at the end of every symbol time (Ts), thereby making it possible to follow the evolution of the calculated response of each cell in real-time, without having to wait for the end of an m-sequence.

8. The system set forth in claim 7, wherein the processor performs the updating operation, after a selected number (k) of symbol times (Ts) to obtain the response of a q-th cell associated with an m-sequence translated by a number (q) of symbols from the mother m-sequence, by cross-correlating the data extracted from the overall response not with the translated m-sequence, but with a version thereof cyclically delayed by the number (k) to obtain the current response of the q-th cell due to a number (N) of most recent stimuli.

9. The system set forth in claim 7, wherein the processor interprets either the calculated wave-forms associated with the various cells directly or those associated with a pattern made up of luminous, isoluminant or gray-scale chromatic stimuli that mirrors the matrix of the stimuli.

10. The system set forth in claim 7, wherein the processor evaluates the accuracy of the acquisition step based on an intrinsic coefficient of variation (CV) and a standard error of the mean (SEM) of the result obtained in real-time.

11. The system set forth in claim 10, wherein the intrinsic coefficient of variation (CV) and the standard error of the mean (SEM) are calculated in accordance with

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and 

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M = σ

A N c .

12. The system set forth in claim 7, wherein the processor comprises a storage member of a normative database that includes results obtained on normal subjects, the result obtained from the patient examined being compared to the database, so as to indicate deviation of the subject compared to the average of normal subjects relative to age.

13. The system set forth in claim 7, wherein between the patient and the display, an optical beam separator is arranged, suitable for allowing the patient to observe the stimulation reflected by the divider instead of directly from the display, thus enabling a medical operator, for control purposes, to observe the retina base of the patient during the course of examination.

14. The system set forth in claim 13, wherein the optical beam separator, the display and ophthalmoscopic member for observing the retina base of the patient during the course of examination, are stably integrated in a single optical-mechanical assembly.

15. A program-controlled apparatus for determining the topography of bioelectric response signals of a visual system of a patient, the patient'"'"'s retina, optical nerve or a projection thereof being at the level of the central cortex, following visual stimulation through a surface arranged in front of the patient'"'"'s eye, which performs the steps of:

(i) displaying an image comprising a plurality of cells as stimulation, each cell being activated or deactivated according to a corresponding digital time function represented by a cyclical succession of binary m-sequences of a first selected duration formed from a plurality of activation symbols, each having a second selected duration, the m-sequences of the various cells being obtained cyclically from a mother m-sequence;

(ii) determining the total bioelectric response of the visual system, the response associated with each cell being determined by the total response of the visual system by a cross-correlation with a suitable translated version of a mother m-sequence, wherein calculation of the response of each cell is updated at the end of each symbol time (Ts), thereby making it possible to follow the evolution of the calculated response of each cell in real-time, without awaiting the end of an m-sequence.

16. The apparatus set forth in claim 15, wherein the process is stored in a memory support device.

17. The apparatus set forth in claim 15, wherein the process is stored in the processor of the system.