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USE OF A VARICELLOVIRUS TAP-INHIBITOR FOR THE INDUCTION OF TUMOR-OR VIRUS-SPECIFIC IMMUNITY AGAINST TEIPP

  • US 20100092435A1
  • Filed: 12/07/2007
  • Published: 04/15/2010
  • Est. Priority Date: 12/07/2006
  • Status: Abandoned Application
First Claim
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1. An in vitro method for producing a cell that induces CD8+ T lymphocytes that selectively recognize cells presenting T cell epitopes associated with impaired peptide processing (TEIPP), the method comprising treating the cell with an effective amount of a varicellovirus TAP-inhibitor, which has the following properties:

  • a) is a protein with at least 50% amino acid sequence identity with at least one of SEQ ID NO;

    1, SEQ ID NO;

    2, SEQ ID NO;

    3 and SEQ ID NO;

    4 or is a nucleic acid encoding said protein; and

    ,b) the TAP inhibitor protein reduces by at least 50% TAP-dependent transport of fluorescein-conjugated synthetic peptide CVNKTERAY (SEQ ID NO;

    14) into cells of human melanoma MEL-JUSO cell line that stably express the TAP-inhibitor as compared to TAP-dependent transport of the fluorescein-conjugated peptide into human melanoma MEL-JUSO cells that do not express the TAP-inhibitor.

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