Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
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Abstract
A method is described for treating or preventing a bone loss disease or a bone loss disorder in a mammalian subject or reducing the incidence of a bone loss disease or a bone loss disorder or alleviating the symptoms thereof. The method includes providing to the mammalian subject at least one treatment regimen including at least one follicle-stimulating hormone modulator configured to and in an amount sufficient to reduce bioactivity or bioavailability of follicle-stimulating hormone in the mammalian subject.
104 Citations
102 Claims
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1-58. -58. (canceled)
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59. A method for maintaining a substantially physiological cyclic pre-menopausal level of follicle-stimulating hormone in a female subject comprising:
providing to the mammalian subject at least one treatment regimen including at least one follicle-stimulating hormone modulator configured to and in an amount sufficient to reduce bioactivity or bioavailability of follicle-stimulating hormone in the female subject, and to approximate the level of bioactive or bioavailable follicle-stimulating hormone to a target cyclic physiological pre-menopausal effective level in the female subject. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84)
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85. A system, comprising:
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a sensor configured to detect one or more hormones in one or more tissues of the mammalian subject; and a controller in communication with the sensor, wherein the controller is configured to provide at least one treatment regimen including at least one follicle-stimulating hormone modulator configured to and in an amount sufficient to reduce bioactivity or bioavailability of follicle-stimulating hormone in the mammalian subject, and to approximate the level of bioactive or bioavailable follicle-stimulating hormone to a target cyclic physiological pre-disease effective level in the mammalian subject. - View Dependent Claims (86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101)
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102-104. -104. (canceled)
Specification