Dispenser device for and a method of dispensing a substance onto a substrate

• US 20100092683A1
• Filed: 09/24/2007
• Published: 04/15/2010
• Est. Priority Date: 09/22/2006
• Status: Abandoned Application

• Current Assignee: Clondiag GmbH (Abbott Laboratories)
• Original Assignee: Clondiag GmbH (Abbott Laboratories)
• Inventors: Kirst, Matthias, Fischer, Jaochim, Ermantraut, Eugen, Schulz, Torsten, Weicherding, Daniel, Poser, Siegfried
• Application Number:
  US12/442,471
• Publication Number:
  US 20100092683A1
• Time in Patent Office: Days
• US Class Current: 427/424
• CPC Class Codes: G01N 2001/4027 evaporation leaving a concentrated sample
• CPC Class Codes: G01N 2035/00158 Elements containing microarrays, i.e. "biochip"
• CPC Class Codes: G01N 2035/1037 Using surface tension, e.g. pins or wires
• CPC Class Codes: G01N 2035/1039 Micropipettes, e.g. microcapillary tubes
• CPC Class Codes: G01N 35/028 having reaction cells in the form of microtitration plates
• CPC Class Codes: G01N 35/1011 Control of the position or alignment of the transfer device
• CPC Class Codes: G01N 35/109 with two horizontal degrees of freedom

Abstract

A dispenser device (100) for dispensing a substance (101) onto a substrate (102), the dispenser device (100) comprising a gripper unit (103) adapted for gripping a container (104) including the substance (101), a first motion mechanism (116, 117) adapted for moving the gripper unit (103) and the substrate (102) relative to each other within a planar region (106), and a second motion mechanism (115, 201 and 209) adapted for moving the gripper unit (103) and the substrate (102) relative to each other in a direction (108) essentially perpendicular to the planar region (106) to thereby dispense the substance (101) to a surface portion (109) of the substrate (102), wherein the first motion mechanism (115) and the second motion mechanism (116, 117) are decoupled from one another.

Claims

1-154. -154. (canceled)

155. A dispenser device for dispensing a substance onto a substrate, the dispenser device comprising

a first motion mechanism configured for moving a container including the substance and the substrate relative to each other within a planar region;

a second motion mechanism configured for moving the container including the substance and the substrate relative to each other in a direction essentially perpendicular to the planar region to thereby dispense the substance to a surface portion of the substrate; and

a gripper unit configured for holding the container including the substance.

156. The dispenser device of claim 155,

wherein the second motion mechanism comprises

a drive unit configured to drive an adapter, a first repeller coupled to the adapter and a second repeller coupled to the gripper unit, the first repeller and the second repeller being configured to generate a repulsive force between the adapter and the gripper unit.

157. The dispenser device of claim 156,

wherein the first repeller and the second repeller are configured to generate the repulsive force in the direction which is essentially opposite to a direction of a gravitational force acting on the gripper unit.

158. The dispenser device of claim 157,

wherein the first and the second repellers are magnetic elements configured to generate the repulsive force.

159. The dispenser device of claim 156,

comprising a detection unit configured for inspecting the substrate for determining whether the substance has been dispensed to the surface portion of the substrate successfully.

160. The dispenser device of claim 156,

comprising a sensor mechanism configured for sensing when the container abuts against the surface portion of the substrate to dispense the substance to the surface portion of the substrate.

161. The dispenser device of claim 160,

wherein the sensor mechanism comprises one of the group consisting of an electric sensor sensing the abutment by a disconnection of an electric contact, an optical sensor sensing the abutment by an optical signal of a light barrier being affected by the abutment, and a pressure sensor being affected by the abutment.

164. A method of using a dispenser device according to any one of claim 156 and claim 162 for the manufacture of a microarray.

162. A device, comprising:

a receiving member configured to receive a substrate having a surface upon which at least one substance is to be dispensed,

a second member movable by an actuator through an actuation motion comprising a deposition motion toward the surface and, thereafter, a return motion away from the surface,

a first member coupled to the second member, the first member comprising the substance to be dispensed,

wherein, during the deposition motion, the actuator is configured to move the second member toward the surface after the first member contacts the surface.

163. The device of claim 162,

wherein the first member comprises a magnetic field generator;

wherein the second member comprises a magnetic field generator;

wherein the magnetic field generators of the first member and the second member oppose a gravitational force of the first member when in contact with the surface.

165. A method, comprising:

supporting a first member by a second member, the first member comprising a substance to be dispensed,

moving the first and second members toward a surface of a substrate upon which the substance is to be dispensed,

after contacting the substance and the surface, stopping to move the first member and continuing to move the second member toward the surface.

166. The method of claim 165,

with the first member in contact with the surface, only in part magnetically opposing a gravitational force exerted by the first member on the surface.

167. The method of claim 166,

after in part magnetically opposing the gravitational force, moving the first and the second member away from the surface.

168. A method, comprising:

supporting a first member by a second member, the first member comprising a substance to be dispensed,

moving the first and second members toward a surface of a substrate upon which the substance is to be dispensed,

prior to contact between the substance and the surface, increasing an absolute difference between a velocity of the first member and a velocity of the second member, and

after increasing the absolute difference between the velocities, contacting the substance to be dispensed and the surface.

169. A method, comprising:

supporting a first member by a second member, the first member comprising a substance to be dispensed,

moving the first and second members along an axis toward a surface of a substrate upon which the substance is to be dispensed,

prior to contact between the substance and the surface, increasing an absolute difference between a velocity of the first member along the axis and a velocity of the second member along the axis, and

after increasing the absolute difference between the velocities, contacting the substance to be dispensed and the surface.

170. The method of claim 169, wherein increasing the absolute difference between the velocities comprises reducing the speed of the second member relative to the speed of the first member.

171. The method of claim 170, wherein reducing the speed of the second member comprises stopping the motion of the second member toward the substrate and the method comprises continuing to move the first member for a distance toward the substrate after stopping motion of the second member and prior to contacting the substance to be dispensed and the surface.

172. The method of claim 171, comprising continuing to move the first member for the distance of at least 250 microns toward the substrate after stopping the second member and prior to contacting the substance to be dispensed and the surface.

173. The method of claim 171, comprising continuing to move the first member for the distance of no more than 500 microns toward the substrate after stopping the second member and prior to contacting the substance to be dispensed and the surface.

174. The method of claim 171, comprising contacting the first member and the surface after reducing the speed of the second member relative to the speed of the first member.

175. The method of claim 171, wherein supporting the first member with the second member comprises levitating the first member with respect to the second member.

176. The method of claim 175, wherein levitating the first member comprises magnetically levitating the first member with respect to the second member.

177. A device, comprising:

a positioning member configured to receive a substrate having a surface upon which at least one substance is to be dispensed and to position the substrate in each of multiple positions within a first dimension,

a dispensing member movable by an actuator through an actuation motion along an axis fixed in space and having a non-zero angle with respect to the first dimension, the actuation motion comprising a deposition motion along the axis toward the surface and, thereafter, a return motion along the axis away from the surface,

wherein;

during operation, the positioning member positions the surface in each of multiple positions with respect to the dispensing member and the actuation motion of the dispensing member along the fixed axis dispenses material to each of multiple spaced apart locations of the surface.