OLIGOMERIC COMPOUNDS FOR THE MODULATION OF HIF-1alpha EXPRESSION
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Abstract
Oligonucleotides directed against the hypoxia-inducible factor-1α (HIP-1α) gene are provided for modulating the expression of HIF-1α. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1α. Methods of using these compounds for modulation of HIF-1α expression and for the treatment of diseases associated with the hypoxia-inducible factor-1α are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
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Citations
41 Claims
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1-24. -24. (canceled)
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25. A method of inhibiting the expression of HIF-1α
- in a cell, comprising contacting the cell with an effective amount of an oligonucleotide compound having the base sequence set forth in SEQ ID NO;
. - View Dependent Claims (26, 37, 38, 39, 40)
- in a cell, comprising contacting the cell with an effective amount of an oligonucleotide compound having the base sequence set forth in SEQ ID NO;
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27-30. -30. (canceled)
- 31. A method of inhibiting the proliferation of a cancer cell comprising contacting said cell with an effective amount of an oligonucleotide compound having the base sequence set forth in SEQ ID NO:
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32-36. -36. (canceled)
Specification