Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
First Claim
1. A method of inhibiting proliferation of tumor cells, the method comprising administering to the tumor cells an exogenous polynucleotide encoding a Sef polypeptide (SEQ ID NO:
- 6), said SEF polypeptide being capable of inhibiting cell proliferation.
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Accused Products
Abstract
A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors are provided. Specifically, the method is effected by administering to a subject in need thereof an agent capable of upregulating the expression level and/or activity of at least a functional portion of Sef, wherein the functional portion being capable of inhibiting RTK-mediated cell proliferation. Also provided are methods and kits for diagnosing and staging of cancer by detecting the expression level of hSef in a tissue sample, wherein a decrease in hSef expression level is indicative of cancer.
5 Citations
33 Claims
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1. A method of inhibiting proliferation of tumor cells, the method comprising administering to the tumor cells an exogenous polynucleotide encoding a Sef polypeptide (SEQ ID NO:
- 6), said SEF polypeptide being capable of inhibiting cell proliferation.
- View Dependent Claims (3, 4, 5, 6, 7, 31)
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2. A method of inhibiting a growth of a solid tumor in a subject, the method comprising administering to the subject an exogenous polynucleotide encoding a Sef polypeptide (SEQ ID NO:
- 6), said SEF polypeptide being capable of inhibiting cell proliferation, thereby inhibiting the growth of the solid tumor in the subject.
- View Dependent Claims (32)
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8. A pharmaceutical composition useful for inhibiting a growth of a solid tumor in a subject comprising, as an active ingredient, an exogenous polynucleotide encoding a Sef polypeptide (SEQ ID NO:
- 6), and a pharmaceutically acceptable carrier.
- View Dependent Claims (9, 10, 11, 12, 13, 33)
- 14. A method of diagnosing cancer in a subject in need thereof, the method comprising detecting in a tissue sample of the subject an expression level of Sef, wherein a decrease in said expression level of said Sef compared to said expression level of said Sef in an unaffected tissue is indicative of the cancer, thereby diagnosing the cancer in the subject in need thereof.
- 27. A kit for diagnosing cancer in a subject in need thereof, the kit comprising a reagent for detecting an expression level of Sef and instructions for use in diagnosing the cancer, said instructions indicate that a decrease in said expression level of said Sef compared to said expression level of said Sef in an unaffected tissue is indicative of the cancer.
Specification