METHOD AND APPARATUS FOR MEDICAL IMAGING USING NEAR-INFRARED OPTICAL TOMOGRAPHY COMBINED WITH PHOTOACOUSTIC AND ULTRASOUND GUIDANCE
First Claim
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1. A method for medical imaging comprising:
- scanning a tissue volume with a near-infrared photoacoustic laser beam to obtain a first set of structural parameters, wherein the tissue volume includes a biological entity;
receiving from the tissue an acoustic signal in response to scanning the tissue volume with the laser beam;
the acoustic signal being processed to obtain a first set of structural parameters;
scanning the tissue with ultrasonic waves to obtain a second set of structural parameters;
scanning the tissue with near-infrared diffusive light to obtain a third set of structural parameters; and
processing the first and second sets of structural parameters and localizing the biological entity using these parameters to quantitatively reconstruct the functional parameters of the biological entity from the third set of structural parameters.
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Abstract
Disclosed herein is an apparatus for biological imaging comprising a probe comprising an emitter and a detector; a source circuit connected in operational communication to the emitter; a detector circuit connected in operational communication to the detector; a central processing unit connected to the source circuit and the detector circuit; a display operably connected to the central processing unit; and wherein the apparatus is capable of photoacoustic tomography and diffusive optical tomography and/or ultrasound tomography.
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Citations
24 Claims
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1. A method for medical imaging comprising:
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scanning a tissue volume with a near-infrared photoacoustic laser beam to obtain a first set of structural parameters, wherein the tissue volume includes a biological entity; receiving from the tissue an acoustic signal in response to scanning the tissue volume with the laser beam;
the acoustic signal being processed to obtain a first set of structural parameters;scanning the tissue with ultrasonic waves to obtain a second set of structural parameters; scanning the tissue with near-infrared diffusive light to obtain a third set of structural parameters; and processing the first and second sets of structural parameters and localizing the biological entity using these parameters to quantitatively reconstruct the functional parameters of the biological entity from the third set of structural parameters. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An apparatus for biological imaging comprising:
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a probe comprising an emitter and a detector; a source circuit connected in operational communication to the emitter; a detector circuit connected in operational communication to the detector; a central processing unit connected to the source circuit and the detector circuit; a display operably connected to the central processing unit; and
,wherein the apparatus is operative to perform photoacoustic tomography and diffusive optical tomography and/or ultrasound tomography. - View Dependent Claims (10, 11, 12, 13)
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14. A probe comprising:
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a faceplate having a first surface and a second surface;
the first surface being opposed to the second surface;
the faceplate having openings for accommodating a plurality of first emitters and second emitters;an ultrasound transducer;
the ultrasound transducer being disposed in the faceplate and having a surface that is parallel to the first surface of the faceplate;
a perimeter of the ultrasound transducer being surrounded by light absorbing material;first emitters; and second emitters;
wherein the first emitters are closer to a center of the faceplate than the second emitters. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification