SYSTEMS AND METHODS FOR DELIVERING A MEDICAMENT

• US 20100094195A1
• Filed: 03/02/2007
• Published: 04/15/2010
• Est. Priority Date: 03/03/2006
• Status: Active Grant

• Current Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Original Assignee: Smith & Nephew Incorporated (Smith & Nephew PLC)
• Inventors: Rose, John NMI, Whitehurst, Lee, Janna, Sied W., Austin, Gene Edward, Rains, James K.
• Granted Patent: US 9,849,216 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

A medicament containment device (106) is provided containing a medicament (114) and is associated with an implant, such as an orthopaedic implant (102). The medicament containment device (106) can degrade upon exposure to energy, such as energy (112) from an energy source (110). The orthopaedic implant (102), including the medicament containment device is implanted or inserted into an environment (100) such as a patient'"'"'s body. The energy source (110) can be used outside the patient'"'"'s body, but in proximity to the orthopaedic implant (102), to apply energy (112) to the medicament containment device (106). Upon exposure to the energy (112), the medicament containment device (106) can degrade and release the medicament (114) into the environment (100). The medicament (114) can kill and/or disrupt bacterial cells (108) or other infectious cells that form in proximity to the orthopaedic implant (102).

Claims

1. A medicament containment device for association with an implant, the medicament containment device comprising:

a medicament;

a first layer substantially surrounding a second layer, the second layer substantially surrounding the medicament;

wherein the first layer is adapted to at least partially degrade when the first layer is exposed to energy from an energy source; and

wherein the second layer is adapted to at least partially degrade and release at least part of the medicament after the first layer degrades.

2. The medicament containment device of claim 1, wherein the first layer at least partially exposes the second layer to an environment;

and wherein the second layer is a resorbable layer and is adapted to at least partially degrade after exposure to the environment.

3. The medicament containment device of claim 1, further comprising:

a first medicament between the first layer and the second layer, wherein the medicament substantially surrounded by the second layer is a second medicament.

4. The medicament containment device of claim 1, wherein the first layer is adapted to degrade at a first resonant frequency and the second layer is adapted to degrade at a second resonant frequency.

5. The medicament containment device of claim 1, wherein the implant is a resorbable implant adapted to degrade over a period of time and the medicament is a resorbtion acceleration agent;

and wherein the resorbtion acceleration agent is adapted to increase the rate of degradation by the resorbable implant.

6. The medicament containment device of claim 1, wherein the energy is at least one of an ultrasound wave, thermal, light wave, radar, sonar, ultraviolet light wave, microwave, electrical, magnetic field, vibratory, and laser.

7. The medicament containment device of claim 1, wherein the implant is an orthopaedic implant.

8. A method for delivering a medicament from a medicament containment device, the medicament containment device having at least one layer containing the medicament, the method comprising:

associating the medicament containment device with an implant, the implant being implanted into a patient body;

applying energy to the medicament containment device;

at least partially degrading the at least one containment device layer with the applied energy; and

releasing the medicament from the medicament containment device after the at least one layer at least partially degrades.

9. The method of claim 8, further comprising:

providing the medicament containment device having a first layer and a second layer, the first layer substantially surrounding the second layer and the second layer substantially surrounding the medicament.

10. The method of claim 9, further comprising;

at least partially degrading the first layer with the applied energy;

at least partially degrading the second layer; and

releasing the medicament from the medicament containment device after the second layer at least partially degrades.

11. The method of claim 9, further comprising:

exposing the second layer to an environment after the first layer at least partially degrades; and

wherein the second layer at least partially degrades after exposure to the environment.

12. The method of claim 8, wherein associating the medicament containment device with the implant comprises attaching the medicament containment device to the implant.

13. The method of claim 12, wherein attaching the medicament containment device to the implant comprises:

providing a pool comprising a plurality of medicament containment devices;

applying an adhesive paste to the implant; and

dipping the implant having adhesive paste into the pool.

14. The method of claim 8, wherein associating the medicament containment device with the implant comprises inserting the medicament containment device in proximity to the implant in a patient body.

15. The method of claim 8, wherein the at least one layer is a seal.

16. The method of claim 8, wherein the implant is an orthopaedic implant.

17. A system comprising:

an energy source adapted to release energy;

an implant in a patient body comprising a medicament containment device, the medicament containment device comprising a at least one layer comprising a medicament;

wherein the energy is adapted to at least partially degrade the at least one layer; and

wherein the medicament containment device is adapted to release at least part of the medicament after the at least one layer at least partially degrades.

18. The system of claim 17, wherein the energy source is located inside the patient body.

19. The system of claim 17, wherein the energy source is located outside the patient body.

20. The system of claim 17, wherein the medicament containment device comprises:

a well reservoir adapted to store the medicament;

a seal; and

wherein the seal is adapted to at least partially degrade after exposure to the energy.

21. The system of claim 17, wherein the energy is adapted to disrupt bacteria colonies around the implant.

22. The system of claim 17, wherein the medicament containment device comprises:

a first layer substantially surrounding a second layer;

the second layer substantially surrounding the medicament;

wherein the first layer is adapted to at least partially degrade when the first layer is exposed to energy from an energy source; and

wherein the second layer is adapted to at least partially degrade and release at least part of the medicament after the first layer degrades.

23. The system of claim 21, further comprising:

a first medicament between the first layer and the second layer, wherein the medicament substantially surrounded by the second layer is a second medicament.

24. The system of claim 22, wherein the first layer is adapted to degrade at a first resonant frequency and the second layer is adapted to degrade at a second resonant frequency.

25. The system of claim 24, wherein the energy source is adapted to release energy at the first resonant frequency and the second resonant frequency.

26. The system of claim 22, wherein the second layer is a resorbable layer that is adapted to at least partially degrade after exposure to body tissue.

27. The system of claim 17, wherein the implant is an orthopaedic implant.