POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS
First Claim
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1. A method for manufacturing an electrode for measuring a concentration of an analyte, the method comprising:
- preparing a colloidal dispersion of a blend of a hydrophobic polymer and a hydrophilic polymer in water;
dipping at least a portion of an elongated conductive body into the colloidal dispersion, wherein the elongated conductive body comprises at least one electroactive surface and a first domain comprising an enzyme configured to react with the analyte; and
removing water from the dipped portion to leave behind, on the elongated conductive body, a second domain configured to control a flux of the analyte therethrough, whereby an electrode for measuring a concentration of the analyte is obtained.
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
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Citations
21 Claims
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1. A method for manufacturing an electrode for measuring a concentration of an analyte, the method comprising:
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preparing a colloidal dispersion of a blend of a hydrophobic polymer and a hydrophilic polymer in water; dipping at least a portion of an elongated conductive body into the colloidal dispersion, wherein the elongated conductive body comprises at least one electroactive surface and a first domain comprising an enzyme configured to react with the analyte; and removing water from the dipped portion to leave behind, on the elongated conductive body, a second domain configured to control a flux of the analyte therethrough, whereby an electrode for measuring a concentration of the analyte is obtained. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An electrode for measuring an analyte concentration, prepared by a process comprising:
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preparing a colloidal dispersion of a blend of a hydrophobic polymer and a hydrophilic polymer in water; dipping at least a portion of an elongated conductive body into the colloidal dispersion, wherein the elongated conductive body comprises at least one electroactive surface and a first domain comprising an enzyme configured to react with the analyte; and removing water from the dipped portion to leave behind, on the elongated conductive body, a second domain configured to control a flux of the analyte therethrough. - View Dependent Claims (17, 18, 19, 20, 21)
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Specification