COMPOSITIONS AND METHODS FOR BLOOD-BRAIN BARRIER DELIVERY OF ORGANOPHOSPHATASES
First Claim
1. A method for treating organophosphate intoxication in a subject in need thereof, comprising systemically administering to the subject a dose of a fusion antibody having organophosphatase activity and binding to the extracellular domain of a receptor expressed on the BBB.
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Accused Products
Abstract
Provided herein are compositions and related methods for delivering an organophosphatase to the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a receptor expressed on the surface of the blood-brain barrier (BBB receptor) and an organophosphatase. In some embodiments, the compositions described herein are used to treat a subject suffering from or at high risk of exposure to an organophosphate (e.g., a nerve gas).
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Citations
22 Claims
- 1. A method for treating organophosphate intoxication in a subject in need thereof, comprising systemically administering to the subject a dose of a fusion antibody having organophosphatase activity and binding to the extracellular domain of a receptor expressed on the BBB.
- 10. A method for protecting a subject from organophosphate intoxication comprising systemically administering to a subject at high risk of organophosphate intoxication a dose of a fusion antibody having organophosphatase activity and binding to the extracellular domain of a receptor expressed on the BBB.
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15. A method for treating of cerebral atherosclerosis, comprising administering to a subject in need thereof a dose of a fusion antibody that has organophosphatase activity and binds to the extracellular domain of a receptor expressed on the BBB.
- 16. A fusion antibody comprising a heavy chain immunoglobulin or a light chain immunoglobulin covalently linked to an organophosphatase, wherein the fusion antibody binds to the extracellular domain of a receptor expressed on the BBB.
Specification