METHODS AND DEVICES FOR MONITORING PLATELET FUNCTION
First Claim
1. A method of monitoring platelet function comprising:
- passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and
monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass, wherein the blood passes through the passageway in one direction and only one time.
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Accused Products
Abstract
A method of monitoring platelet function comprising: passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass, wherein the blood passes through the passageway in one direction and only one time. A method of monitoring platelet function comprising: passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass, wherein the blood is recirculated through the passageway and the blood flows only one direction through the passageway.
80 Citations
23 Claims
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1. A method of monitoring platelet function comprising:
- passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and
monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass, wherein the blood passes through the passageway in one direction and only one time. - View Dependent Claims (2, 3, 4, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and
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5-6. -6. (canceled)
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18. A device for monitoring platelet function, comprising:
- a fluid-tight material forming a passageway;
a pump functionally linked to the passageway for pumping blood through the passageway;
a shear generating restriction within the passageway;
a spring within the passageway and positioned downstream of the shear generating restriction; and
a detector for detecting the flow of blood through the passageway to detect formation of the platelet mass.
- a fluid-tight material forming a passageway;
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19. A method of monitoring platelet function comprising:
- passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and
monitoring the flow or composition of the blood in the passageway to detect formation of the platelet mass, wherein the blood is recirculated through the passageway and the blood flows only one direction through the passageway. - View Dependent Claims (20, 21, 22)
- passing blood removed from a mammal through a passageway comprising (i) a shear generating restriction to generate a platelet mass in the passageway and (ii) a platelet aggregate trap; and
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23-41. -41. (canceled)
Specification