INTEGRATED BIO-REACTOR MONITOR AND CONTROL SYSTEM

• US 20100099172A1
• Filed: 12/21/2009
• Published: 04/22/2010
• Est. Priority Date: 11/26/2003
• Status: Active Grant

• Current Assignee: New England Controls, Inc. (Enerpac Tool Group Corp.)
• Original Assignee: Broadley James Corporation
• Inventors: West, Larry Eugene
• Granted Patent: US 8,021,871 B2
• Time in Patent Office: Days
• US Class Current: 435/286.1
• CPC Class Codes: C12M 41/48 Automatic or computerized control automatic analysis G01N35/00
• CPC Class Codes: C12Q 3/00 Condition responsive control processes apparatus therefor C12M1/36; controlling or regulating in general G05
• CPC Class Codes: G05B 15/02 electric
• CPC Class Codes: G05D 21/02 characterised by the use of electric means

Abstract

Systems and methods for automatically controlling conditions of a process are disclosed. In one example, a controller is programmed with a sequence of steps and parameters required to carry out a bioreactor process. A sensor system interacts with the bioreactor to receive information related to a condition of the bioreactor and/or receive a sample from the bioreactor, which it analyzes. The sensor system sends data signals related to the information and/or the sample to a controller, which determines a control signal based on the received information. The controller sends the control signal to the sensor system which, based on the control signal, performs an action that affects a condition of the bioreactor or affects the sensor system itself.

Claims

1. A system for controlling a process in a bioreactor, comprising:

a first sensor system comprising one or more sensors connected to the bioreactor, said first sensor system configured to generate one or more data signals related to a condition of the bioreactor;

a first pump system comprising one or more pumps connected to the bioreactor;

a control system for controlling the process in the bioreactor, said control system configured to communicate one or more control signals to said first sensor system wherein the control signals are based on data signals received from said first sensor system; and

a communication network connecting said control system, said first sensor system, and said first pump system;

wherein said control system comprises

a controller configured with a bioreactor control process to control the conditions in a bioreactor by determining control signals based on the bioreactor control process and information received related to a condition in the bioreactor, and further configured to send the control signals over said communication network, and

a utility tower, housed separately from the bioreactor and coupled to said controller via said communication network, said utility tower configured to receive control signals from said controller and to change a condition in the bioreactor based on the control signals,

wherein said first sensor system is configured to provide the one or more data signals related to a condition in the bioreactor to said controller, and

wherein said first pump system is configured to receive control signals from said control system and to supply a liquid substance to the bioreactor in response to the received control signals.

2. The system of claim 1, wherein the one or more data signals generated by the first sensor system relate to a temperature condition of the bioreactor.

3. The system of claim 1, wherein the one or more data signals generated by the first sensor system relate to a pH condition of the bioreactor.

4. The system of claim 1, wherein the one or more data signals generated by the first sensor system relate to a dissolved oxygen (DO) condition of the bioreactor.

5. The system of claim 1, wherein the one or more data signals generated by the first sensor system relate to a glucose condition of the bioreactor.

6. The system of claim 1, wherein the one or more data signals generated by the first sensor system relate to a concentration of dissolved oxygen condition of the bioreactor.

7. The system of claim 1, wherein said controller is configured to analyze the one or more data signals to determine if the one or more data signals fall within a predetermined range of values, and said controller is further configured to generate the one or more control signals based on the analysis of the one or more data signals.

8. The system of claim 1, further comprising a first gas supply system connected to the bioreactor and connected to said control system, said first gas supply system configured to receive control signals and provide a gas to the bioreactor in response to the received control signals.

9. The system of claim 1, wherein said first pump system receives control signals from said controller via the communication network.

10. The system of claim 1, wherein said first gas supply system receives control signals from said controller via the communication network.

11. The system of claim 1, wherein said utility tower comprises an agitation system configured to agitate a solution in the bioreactor in response to a control signal received from said controller.

12. The system of claim 1, further comprising a weigh scale connected to the control system, the weigh scale configured to provide data to the control system.

13. The system of claim 12, wherein the weigh scale provides data to said controller, and the controller is configured to generate a control signal to change a condition in the bioreactor based on the data provided by the weigh scale.

14. The system of claim 12, wherein the weigh scale provides data to the controller communicated via the utility tower, and the controller is configured to generate a control signal to change a condition in the bioreactor based on the data provided by the weigh scale.

15. The system of claim 1, further comprising a second pump system comprising one or more pumps connected to a second bioreactor, wherein the second pump system is configured to receive control signals from the control system to supply a liquid substance to the second bioreactor in response to received control signals.

16. The system of claim 8, further comprising:

a second pump system comprising one or more pumps connected to a second bioreactor, wherein the second pump system is configured to receive control signals from the control system to supply a liquid substance to the second bioreactor in response to control signals received from said control system; and

a second gas supply system connected to the second bioreactor, wherein the second gas system is configured to receive control signals from the control system to supply a gas to the second bioreactor in response to control signals received from the control system.

17. The system of claim 1, further comprising a computer configured to store an electronic history of the bioreactor control process.

18. The system of claim 17, wherein the electronic history comprises information on an event that occurred during the bioreactor control process.

19. The system of claim 17, wherein the electronic history comprises information on the amount of gas added or removed from the bioreactor, the type of gas added or removed from the bioreactor, the amount of fluid added or removed from the bioreactor, the type of fluid added or removed from the bioreactor, the duration of the agitation, or the speed of an impeller during the agitation.

20. The system of claim 17, wherein the electronic history comprises information on the time the addition or removal of gas started, the time the addition or removal of gas ended, the time the addition or removal of fluid started, the time the addition or removal of fluid ended, the time agitation started, or the time agitation ended.

21. The system of claim 18, wherein the event comprises addition or removal of a gas from the bioreactor, addition or removal of a fluid from the bioreactor, or agitation provided to a bioreactor.

22. The system of claim 17, wherein the electronic history comprises information transmitted from the controller to the utility tower.

23. The system of claim 22, wherein the information comprises a command entered into the controller via a local input device.

24. The system of claim 17, wherein the computer is housed separately from the utility tower.

25. The system of claim 17, wherein the computer is housed separately from the control system and connected to be in communication with the controller.