Tamper resistant oral dosage forms containing an embolizing agent
First Claim
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1. A dosage form for oral administration comprising a therapeutically effective amount of a drug that is susceptible to abuse and an effective amount of an embolizing agent wherein, following tampering of the dosage form and administration of the tampered dosage form to a non-oral site of administration, the embolizing agent forms an embolus or a coagulation at the site of the administration.
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Abstract
Oral dosage form containing a therapeutically effective amount of a drug susceptible to abuse and an effective amount of an embolizing agent which causes the production of a solid or semi-solid embolus or blockage after tampering.
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Citations
20 Claims
- 1. A dosage form for oral administration comprising a therapeutically effective amount of a drug that is susceptible to abuse and an effective amount of an embolizing agent wherein, following tampering of the dosage form and administration of the tampered dosage form to a non-oral site of administration, the embolizing agent forms an embolus or a coagulation at the site of the administration.
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19. A method for inhibiting abuse of an oral dosage form containing a drug subject to abuse comprising providing a dosage form for oral administration which dosage form comprises a therapeutically effective amount of a drug that is susceptible to abuse and an effective amount of an embolizing agent wherein, following tampering of the dosage form and administration of the tampered dosage form to a non-oral site of administration, the embolizing agent forms an embolus or a coagulation at the site of the administration.
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20. A method for making an oral dosage form that is resistant to abuse comprising combining a therapeutically effective amount of a drug that is susceptible to abuse and an amount of an embolizing agent that is effective to cause the formation of an embolus or a coagulation when the dosage form is tampered with and administered to a non-oral site of administration.
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