TRITERPENE COMPOUNDS WHICH ARE EFFECTIVE ON IMPROVEMENT OF BRAIN FUNCTION

• US 20100099763A1
• Filed: 12/21/2009
• Published: 04/22/2010
• Est. Priority Date: 10/10/2003
• Status: Active Grant

• Current Assignee: Bongcheol Kim, Chang-Kyun Han, Chil Mann Jung, Guang-Jin Im, Se Jun Yun, Soomin Lee, Tae Kon Kim, Wie-Jong Kwak, Wonrack Choi
• Original Assignee: Bongcheol Kim, Chang-Kyun Han, Chil Mann Jung, Guang-Jin Im, Se Jun Yun, Soomin Lee, Tae Kon Kim, Wie-Jong Kwak, Wonrack Choi
• Inventors: Kim, Bongcheol, CHOI, Wonrack, Jung, Chil Mann, Lee, Soomin, Kwak, Wie-Jong, Yun, Se Jun, Kim, Tae Kon, Han, Chang-Kyun, Im, Guang-Jin
• Granted Patent: US 8,790,687 B2
• Time in Patent Office: Days
• US Class Current: 514/557
• CPC Class Codes: A23L 33/10 using additives addition of substantially indigestible substances A23L33/21
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/322 having an effect on the health of the nervous system or on mental function
• CPC Class Codes: A23V 2250/1592 Iron
• CPC Class Codes: A23V 2250/1642 Zinc
• CPC Class Codes: A23V 2250/2124 Ginseng
• CPC Class Codes: A23V 2250/214 Tea
• CPC Class Codes: A23V 2250/708 Vitamin C
• CPC Class Codes: A23V 2250/712 Vitamin E
• CPC Class Codes: A61K 31/56 Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to the triterpene compounds improving in brain functions. In particular, the present invention relates to a novel use of the triterpene compounds represented by the Formula 1 for improving decreased memory and a pharmaceutical composition for improving brain functions comprising the triterpene compounds represented by the Formula 1.

Claims

1. A method of improving brain function which comprises administering to a patient in need thereof a therapeutically effective amount of a triterpene compound represented by the Formula 1:

wherein R₁, R₂ and R₄ are independently CH₃ and R₃ is H;

R₁ and R₂ are independently CH₃, R₃ is H and R₄ is CH₂OH;

or R₁, R₃ and R₄ are independently CH₃ and R₂ is H.

3. The method of claim 1, wherein the brain function is memory, perception or learning.

4. The method of claim 1, wherein the triterpene compound is administered to a patient in forms of oral or parenteral formulation with at least one a pharmaceutically acceptable carrier or excipient.

2. A method of treating mild cognitive impairment or dementia which comprises administering to a patient in need thereof a therapeutically effective amount of a triterpene compound represented by the Formula 1:

wherein R₁, R₂ and R₄ are independently CH₃ and R₃ is H;

R₁ and R₂ are independently CH₃, R₃ is H and R₄ is CH₂OH;

or R₁, R₃ and R₄ are independently CH₃ and R₂ is H.

5. The method of claim 2, wherein the triterpene compound is administered to a patient in forms of oral or parenteral formulation with at least one a pharmaceutically acceptable carrier or excipient.