CARDIAC OUTPUT MONITOR WITH COMPENSATION FOR TISSUE PERFUSION
First Claim
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1. A system for determining a physical parameter of the cardiovascular system of a subject comprising:
- a. an illumination system configured to provide an electromagnetic radiation to a detection area to excite an indicator administrated to the cardiovascular system to fluoresce, and to provide said electromagnetic radiation to said detection area for a Doppler flowmetry measurement;
b. a detection system configured to detect the intensity of the indicator fluorescence emerging from the detection area, and to detect the intensity and the frequency distribution of electromagnetic radiation reflected from the detection area; and
c. a computing system configured to compute a parameter of the cardiovascular system by using the indicator fluorescence intensity, to compute a Doppler flowmetry parameter of the detection area by using the reflected electromagnetic radiation intensity and its frequency distribution, and to compensate the cardiovascular system computation for a variation of the blood content of the detection area by using the computed Doppler flowmetry parameter.
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Abstract
A non-invasive system and method for determination of cardiac output and blood volume of a patient includes compensating for a change in the fluorescence of an indicator circulating in the bloodstream of a tissue or organ that is caused by a variation of the blood content at the site of the measurement.
24 Citations
23 Claims
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1. A system for determining a physical parameter of the cardiovascular system of a subject comprising:
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a. an illumination system configured to provide an electromagnetic radiation to a detection area to excite an indicator administrated to the cardiovascular system to fluoresce, and to provide said electromagnetic radiation to said detection area for a Doppler flowmetry measurement; b. a detection system configured to detect the intensity of the indicator fluorescence emerging from the detection area, and to detect the intensity and the frequency distribution of electromagnetic radiation reflected from the detection area; and c. a computing system configured to compute a parameter of the cardiovascular system by using the indicator fluorescence intensity, to compute a Doppler flowmetry parameter of the detection area by using the reflected electromagnetic radiation intensity and its frequency distribution, and to compensate the cardiovascular system computation for a variation of the blood content of the detection area by using the computed Doppler flowmetry parameter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of measuring a physical parameter of the cardiovascular system of a subject comprising:
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a. administering to the cardiovascular system of a subject a detectable amount of at least one indicator; b. providing an electromagnetic radiation to a detection area by using an illumination system to excite the indicator present at the detection area to fluoresce; c. detecting the indicator fluorescence intensity emitted from the detection area by using a detection system; d. detecting the intensity and the frequency distribution of the reflected electromagnetic radiation from the detection area for a Doppler flowmetry measurement by using said detection system, e. computing at least one physical parameter of the cardiovascular system using the detected indicator fluorescence intensity, and f. compensating the physical parameter of the cardiovascular system for variations of the blood content of the detection area by using the Doppler flowmetry measurement. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification