Intravitreal injection device and system

• US 20100100054A1
• Filed: 06/16/2009
• Published: 04/22/2010
• Est. Priority Date: 10/21/2008
• Status: Active Grant

• Current Assignee: Gholam A. Peyman, Kamran Hosseini, Michel Cormier
• Original Assignee: Gholam A. Peyman, Kamran Hosseini, Michel Cormier
• Inventors: Cormier, Michel, Peyman, Gholam, Hosseini, Kamran
• Granted Patent: US 8,221,353 B2
• Time in Patent Office: Days
• US Class Current: 604/239
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

An intravitreal injection system for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) an injection member coupled to, or comprising, an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a needle having a first end that is in communication with a formulation chamber and a second injection end, and (iii) a movable platform for positioning the system on the eye, guiding the needle, and limiting the penetration depth of the needle into the eye.

Claims

1. An intravitreal injection device, comprising:

an injection member having a formulation chamber, a needle and a transitional guide platform, said formulation chamber being adapted to receive and contain a pharmacological agent formulation therein, said needle having a first end that is in communication with said formulation chamber and a second ejection end, said transitional guide platform having a predetermined degree of flexibility, whereby said transitional guide platform substantially conforms to the surface of a sclera of an eye when in an engagement position thereon.

2. The device of claim 1, wherein the volume of said pharmacological agent formulation is in the range of approximately 0.01-0.2 ml.

3. The device of claim 1, wherein said device provides a predetermined needle penetration depth into said eye in the range of approximately 1-10 mm when said moveable platform is in said engagement position.

4. The device of claim 1, wherein said device includes an injector that is adapted to generate sufficient force to expel said pharmacological agent formulation from said formulation chamber through and out of said needle, said injector providing an injection pressure in the range of approximately 5-200 psi.

5. The device of claim 1, wherein said device includes a fixed platform that cooperates with said transitional guide platform and limits movement of said transitional guide platform.

6. The device of claim 1, wherein said transitional guide platform has a substantially circular shape and a centrally located lumen that is adapted to receive and guide said needle.

8. The device of claim 1, wherein said transitional guide platform includes suction means that provides an engagement force when said guide platform is in said engagement position on said eye.

11. The device of claim 1, wherein said transitional guide platform comprises a moveable guide platform.

12. The device of claim 11, wherein said moveable guide platform is adapted to move along the longitudinal axis of said needle.

13. The device of claim 1, wherein said transitional guide platform comprises a compressible guide platform.

14. The device of claim 13, wherein said compressible guide platform has a thickness in the range of approximately 2-12 mm.

15. The device of claim 13, wherein said compressible guide platform comprises a non-reticulated closed-cell foam.

16. The device of claim 13, wherein said compressible guide platform comprises a reticulated open-cell foam.

17. The device of claim 16, wherein said reticulated cell foam comprises a polymeric material selected from the group consisting of polyvinylchloride, polyurethane, polystyrene, polypropylene, polyethylene, crosslinked polyethylene, ethyl vinyl acetate, polyesters, vinyl nitrile neoprene and mixtures thereof.

18. The device of claim 1, wherein said transitional guide platform comprises a moveable and compressible guide platform.

7. (canceled)

9-10. -10. (canceled)