HEMOSTATIC IMPLANT

• US 20100100123A1
• Filed: 10/05/2009
• Published: 04/22/2010
• Est. Priority Date: 10/17/2008
• Status: Abandoned Application

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Confluent Surgical, Inc. (Medtronic Plc)
• Inventors: Bennett, Steven
• Application Number:
  US12/573,176
• Publication Number:
  US 20100100123A1
• Time in Patent Office: Days
• US Class Current: 606/213
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/129 containing macromolecular fillers
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 1/04 Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose

Abstract

The present disclosure relates to hemostatic implants including a porous substrate having a first hydrogel precursor and a second hydrogel precursor applied thereto in a manner such that the first hydrogel precursor and second hydrogel precursor do not react with each other until the implant is placed at the site of implantation and exposed to the physiological fluids of a patient.

Claims

1. An implant comprising a porous substrate having a first hydrogel precursor applied to the porous substrate and a film containing a second hydrogel precursor applied to the porous substrate.

2. The implant of claim 1 wherein the porous substrate is a foam.

3. The implant of claim 1 wherein the porous substrate is a knitted textile.

4. The implant of claim 1 wherein the porous substrate is a non-woven textile.

5. The implant of claim 1 wherein the porous substrate is made from a bioabsorbable material.

6. The implant of claim 1 wherein the porous substrate is made from a non-bioabsorbable material.

7. The implant of claim 1 wherein the porous substrate is made from oxidized cellulose.

8. The implant of claim 1 wherein the first hydrogel precursor comprises particles.

9. The implant of claim 1 wherein the first hydrogel precursor is a foam.

10. The implant of claim 1 wherein the first hydrogel precursor is a film.

11. The implant of claim 1 further comprising a bioactive agent.

12. An implant comprising a porous substrate having a first hydrogel precursor applied to a first portion of the porous substrate and a second hydrogel precursor applied to a second portion of the porous substrate, the first portion of the substrate being spatially separated from the second portion of the porous substrate.

13. The implant of claim 12 wherein the porous substrate is a foam.

14. The implant of claim 12 wherein the porous substrate is a knitted textile.

15. The implant of claim 12 wherein the porous substrate is a non-woven textile.

16. The implant of claim 12 wherein the porous substrate is made from a bioabsorbable material.

17. The implant of claim 12 wherein the porous substrate is made from a non-bioabsorbable material.

18. The implant of claim 12 wherein the porous substrate is made from oxidized cellulose.

19. The implant of claim 12 wherein the first hydrogel precursor comprises particles.

20. The implant of claim 12 wherein the first hydrogel precursor is a foam.

21. The implant of claim 12 wherein the first hydrogel precursor is a film.

22. The implant of claim 12 wherein the second hydrogel precursor comprises particles.

23. The implant of claim 12 wherein the second hydrogel precursor is a foam.

24. The implant of claim 12 wherein the second hydrogel precursor is a film.

25. The implant of claim 12 further comprising a bioactive agent.

32. A method as in claim 20 wherein the first hydrogel precursor is applied to the porous substrate as a film.

33. A method as in claim 20 wherein the first portion of the substrate is spatially separated from the second portion of the porous substrate.

26. A method comprising

applying a first hydrogel precursor to a porous substrate;

and

applying a film containing a second hydrogel precursor to the porous substrate.

27. A method as in claim 26 wherein applying the first hydrogel precursor to the porous substrate comprises

at least partially submerging at least a first portion of the porous substrate into a solution containing the first hydrogel precursor and a solvent;

and

evaporating the solvent to deposit the first hydrogel precursor within pores of the porous substrate.

28. A method as in claim 26 wherein applying a first hydrogel precursor to the porous substrate comprises

contacting the porous substrate with a film-forming composition containing the first hydrogel precursor and a solvent;

and

evaporating the solvent to deposit a film containing the first hydrogel precursor on at least a portion of the porous substrate.

29. A method as in claim 26 wherein applying a first hydrogel precursor to the porous substrate comprises

simultaneously lyophilizing first and second compositions, the first composition forming the porous substrate and the second composition containing the first hydrogel precursor and a solvent forming a foam containing the first hydrogel precursor.

30. A method comprising

applying a first hydrogel precursor to a first portion of a porous substrate;

applying a second hydrogel precursor to a second portion of the porous substrate,

the first portion of the substrate being spatially separated from the second portion of the porous substrate.

31. A method comprising:

orienting a porous substrate having a first hydrogel precursor applied to a first portion of the porous substrate and a second hydrogel precursor applied to a second portion of the porous substrate, with the first portion nearer to a patient'"'"'s tissue than the second portion; and

contacting the oriented implant with the patient'"'"'s tissue, whereby physiological fluids are wicked through the porous substrate sequentially dissolving the first hydrogel precursor and then the second hydrogel precursor coating.