PET/MR SCANNERS FOR SIMULTANEOUS PET AND MR IMAGING

• US 20100102813A1
• Filed: 01/08/2008
• Published: 04/29/2010
• Est. Priority Date: 01/11/2007
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Overweg, Johan, Solf, Torsten, Schulz, Volkmar, Thon, Andreas
• Granted Patent: US 8,188,736 B2
• Time in Patent Office: Days
• US Class Current: 324/309
• CPC Class Codes: A61B 5/0035 adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/4417 related to combined acquisition of different diagnostic modalities
• CPC Class Codes: A61B 6/5247 combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
• CPC Class Codes: G01R 33/481 MR combined with positron emission tomography [PET] or single photon emission computed tomography [SPECT]
• CPC Class Codes: G01T 1/1603 with a combination of at least two different types of detector see provisionally also G01T1/16

Abstract

In a combined system, a magnetic resonance (MR) scanner includes a magnet (10, 110) configured to generate a static magnetic field (B0) at least in a MR examination region (12) from which MR data are acquired. Radiation detectors (40, 41, 140) are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region (70). The radiation 5 detectors include electron multiplier elements (60, 160) having a direction of electron acceleration (ae) arranged substantially parallel or anti-parallel with the static magnetic field (B0). In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces (14, 15) disposed on opposite sides of a magnetic 10 resonance examination region, and the radiation detectors include first and second arrays (40, 41) of radiation detectors disposed with the first and second spaced apart magnet pole pieces.

Claims

1. A combined magnetic resonance (MR) and positron emission tomography (PET) data acquisition system comprising:

a magnetic resonance scanner including a magnet configured to generate a static magnetic field at least in a magnetic resonance examination region, the magnetic resonance scanner being configured to acquire magnetic resonance data from the magnetic resonance examination region; and

radiation detectors configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography examination region, the radiation detectors including electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field.

2. The acquisition system as set forth in claim 1, wherein the positron emission tomography examination region and the magnetic resonance examination region at least partially overlap.

3. The acquisition system as set forth in claim 2, wherein the radiation detectors include:

first and second parallel planar arrays of radiation detectors arranged to view the positron emission tomography examination region, the first and second parallel planar arrays arranged orthogonal to the static magnetic field.

4. The acquisition system as set forth in claim 3, wherein each planar array of radiation detectors includes:

a planar array of microchannel plate photomultipliers, electron-transmissive microchannels of the microchannel plate photomultipliers being arranged parallel with the static magnetic field; and

a planar array of scintillators arranged parallel with the planar array of microchannel plate photomultipliers and disposed between the planar array of microchannel plate photomultipliers and the positron emission tomography examination region.

5. The acquisition system as set forth in claim 2, wherein the magnetic resonance scanner further includes:

a radio frequency coil including a radio frequency screen or shield, the radio frequency coil having first and second planar portions arranged parallel with the respective first and second parallel planar arrays of radiation detectors.

6. The acquisition system as set forth in claim 1, wherein the magnetic resonance scanner includes a generally cylindrical magnet generating the static magnetic field oriented parallel with a cylinder axis of the generally cylindrical magnet, and the radiation detectors are arranged inside of the generally cylindrical magnet.

8. The acquisition system as set forth in claim 6, wherein the radiation detectors include:

scintillators arranged inside of the generally cylindrical magnet; and

microchannel plate photomultipliers arranged to view the scintillators, electron-transmissive microchannels of the microchannel plate photomultipliers being arranged parallel with the static magnetic field and parallel with the cylinder axis of the generally cylindrical magnet.

9. The acquisition system as set forth in claim 1, wherein the radiation detectors further include scintillators each being optically coupled with a plurality of the electron multiplier elements, the data acquisition system further including:

a processor configured to compute a localized position of a burst of light generated within one of the scintillators based on detected signals from the plurality of electron multiplier elements optically coupled therewith.

10. The acquisition system as set forth in claim 9, further including:

a radio frequency shield disposed between the electron multiplier elements and the examination region.

11. The acquisition system as set forth in claim 1, wherein the magnet generates a static magnetic field between a pair of pole pieces, the radiation detectors being mounted adjacent and parallel to at least one of the pole pieces.

12. A data acquisition method comprising:

(i) acquiring magnetic resonance data using the magnetic resonance scanner of the combined MR and PET data acquisition system of claim 1; and

(ii) acquiring PET data using the radiation detectors of the combined MR and PET data acquisition system of claim 1;

wherein the acquiring (i) and the acquiring (ii) are performed simultaneously.

7. (canceled)

13. A combined magnetic resonance (MR) and positron emission tomography (PET) data acquisition system comprising:

an open magnetic resonance scanner having first and second spaced-apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region and configured to generate a static magnetic field at least in the magnetic resonance examination region having a magnetic field direction directed from the first magnet pole piece to the second magnet pole piece; and

first and second arrays of radiation detectors disposed with the first and second spaced-apart magnet pole pieces and configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography examination region that at least partially overlaps the magnetic resonance examination region.

14. The data acquisition system as set forth in claim 13, wherein the first and second arrays of radiation detectors are first and second planar arrays oriented parallel to each other and transverse to the static magnetic field.

15. The data acquisition system as set forth in claim 14, wherein the radiation detectors of the first and second arrays of radiation detectors include at least one of microchannel plate photomultipliers, avalanche photodiodes (APD'"'"'s), and solid state silicon photomultipliers (SiPM).

16. The data acquisition system as set forth in claim 13, wherein the open magnetic resonance scanner includes:

a radio frequency coil having first and second planar portions arranged parallel with the first and second planar arrays of radiation detectors.

17. The data acquisition system as set forth in claim 13, wherein the radiation detectors of the first and second arrays of radiation detectors include:

microchannel plate photomultipliers having electron-transmissive microchannels arranged parallel with the static magnetic field; and

scintillators arranged to generate bursts of light responsive to interaction with gamma rays, the microchannel plate photomultipliers being optically coupled with the scintillators to detect the generated bursts of light.

19. The data acquisition system as set forth in claim 13, further including:

electronics configured to acquire time-of-flight positron emission tomography data using the first and second arrays of radiation detectors.

18. (canceled)

20. (canceled)

21. A data acquisition method comprising:

generating a static magnetic field at least within a magnetic resonance (MR) examination region;

acquiring MR data from the MR examination region; and

acquiring positron emission tomography (PET) data from a PET examination region at least partially overlapping the MR examination region, the acquiring of PET data including amplifying radiation detection event signals by electron multiplication processes configured such that cross products of velocities of accelerating electrons of the electron multiplication processes and the static magnetic field are substantially nulled.

22. (canceled)

23. A positron emission tomography (PET) data acquisition system comprising:

an array of scintillators surrounding an examination region and configured to generate scintillation events responsive to interaction with gamma rays;

a plurality of microchannel photomultipliers optically coupled with the scintillators to detect the scintillation events; and

a processor configured to reconstruct projection data or spatially localized projection data derived from the detected scintillation events into a reconstructed positron emission tomographic image.

24. The positron emission tomography (PET) data acquisition system as set forth in claim 23, further including:

a non-natural magnetic field, the microchannel photomultipliers arranged with their microchannels oriented parallel with the non-natural magnetic field.

25. (canceled)

26. (canceled)

27. (canceled)

28. An imaging method comprising:

acquiring time-of-flight localized positron emission tomographic projection data from a subject using an array of radiation detectors that incompletely encircle the subject; and

reconstructing an image of the subject from the acquired time-of-flight localized positron emission tomographic projection data, wherein information missing due to the incomplete encirclement of the subject by the array of radiation detectors is compensated by additional information provided by the time-of-flight localization.

29. The imaging method as set forth in claim 28, wherein the projection data are acquired intermittently, the imaging method further including:

acquiring magnetic resonance data during time gaps between the intermittent projection data acquisitions; and

reconstructing an image of the subject from the acquired magnetic resonance data.

30. (canceled)

31. (canceled)

32. (canceled)