REACTIVE SURGICAL IMPLANT
First Claim
Patent Images
1. A medical device comprising:
- a substrate comprising at least one synthetic component;
at least one natural material on at least a portion of a surface of the substrate; and
a reactive component selectively applied to at least a portion of the medical device,wherein the reactive component reacts with the at least one natural material to form at least one crosslinked region on the surface of the substrate.
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Abstract
Biocompatible implants include a polymer substrate and a reactive component selectively applied to the substrate. The reactive component in combination with the substrate creates crosslinked regions on a surface of the substrate. The crosslinked regions may provide a visual aid and/or stiffening element to the implant.
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Citations
21 Claims
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1. A medical device comprising:
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a substrate comprising at least one synthetic component; at least one natural material on at least a portion of a surface of the substrate; and a reactive component selectively applied to at least a portion of the medical device, wherein the reactive component reacts with the at least one natural material to form at least one crosslinked region on the surface of the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of increasing the stiffness of a mesh, the method comprising:
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providing a substrate comprising at least one synthetic component in combination with at least one natural material comprising amine groups on at least a portion of a surface of the substrate; contacting the substrate with a genipin solution; and allowing the natural material and genipin to crosslink thereby creating localized crosslinked regions on the surface of the substrate, wherein the localized crosslinked regions increase stiffness of the mesh. - View Dependent Claims (17, 18, 19)
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20. A surgical mesh comprising:
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a polyester substrate; a collagen film on at least a portion of a surface of the polyester substrate; and a reactive component comprising genipin selectively applied to at least a portion of the mesh, wherein the genipin crosslinks the collagen, thereby increasing stiffness of the mesh. - View Dependent Claims (21)
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Specification