OVER-COATED PRODUCT INCLUDING TABLETED CENTER AND MEDICAMENT

• US 20100104620A1
• Filed: 01/04/2010
• Published: 04/29/2010
• Est. Priority Date: 04/06/1999
• Status: Abandoned Application

• Current Assignee: WM Wrigley Jr Company (Mars Incorporated)
• Original Assignee: WM Wrigley Jr Company (Mars Incorporated)
• Inventors: Wokas, William J., Matulewicz, Leonard, Ream, Ronald L.
• Application Number:
  US12/651,873
• Publication Number:
  US 20100104620A1
• Time in Patent Office: Days
• US Class Current: 424/440
• CPC Class Codes: A23G 2200/04 containing vitamins, antibiotics, other medicaments
• CPC Class Codes: A23G 3/343 Products for covering, coating, finishing, decorating
• CPC Class Codes: A23G 4/20 Composite products, e.g. centre-filled , multi-layer, laminated
• CPC Class Codes: A61K 9/0058 Chewing gums non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00
• CPC Class Codes: A61K 9/209 containing drug in at least two layers or in the core and in at least one outer layer
• CPC Class Codes: A61P 25/26 Psychostimulants, e.g. nicotine, cocaine

Abstract

Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted center. The tableted center is defined by compressible excipients. By chewing the product, the medicament or agent is released from the product within the buccal cavity.

Claims

1. A product comprising a medicament comprising:

a compressed center comprising at least one compressible saccharide or sugar alcohol; and

a coating comprising a medicament that surrounds the compressed center, the coating comprising at least 50% by weight of the product.

2. The product of claim 1, wherein the medicament is selected from the group consisting of analgesics, muscle relaxants, antibiotics, antivirals, stimulants, antihistamines, decongestants, anti-inflammatories, antacids, psychotherapeutic agents, insulin, vitamins, minerals, nutraceuticals, nutritional supplements, cardiovascular agents, and combinations thereof.

3. The product of claim 1, wherein the coating includes a taste masking agent.

4. The product of claim 3, wherein the taste masking agent is selected from the group consisting of zinc gluconate, ethyl maltol, glycine, acesulfame-k, aspartame, saccharin, fructose, xylitol, isomalt, maltitol, spray dried licorice root, glycerrhizine, sodium gluconate, glucono delta-lactone, ethyl vanillin, dextrose, sucralose, vanillin, ethyl maltol, and combinations thereof.

5. The product of claim 3, wherein the taste masking agent comprises approximately 30% to about 99% by weight of the coating.

6. The product of claim 1, wherein the coating includes approximately 0.1% to about 5% by weight of a high-intensity sweetener selected from the group consisting of aspartame, sucralose, saccharine, acesulfame-k, and combinations thereof.

7. The product of claim 1, wherein the compressed center includes dextrose.

8. The product of claim 1, wherein the coating does not have a shellac layer.

9. A product comprising a medicament comprising:

a compressed center comprising at least one saccharide or sugar alcohol; and

a coating comprising a medicament that surrounds the center, the coating comprising at least 50% by weight of the product.

10. The product of claim 9, wherein the medicament is selected from the group consisting of analgesics, muscle relaxants, antibiotics, antivirals, stimulants, antihistamines, decongestants, anti-inflammatories, antacids, psychotherapeutic agents, insulin, vitamins, minerals, nutraceuticals, nutritional supplements, cardiovascular agents, and combinations thereof.

11. The product of claim 9, wherein the coating comprising a taste masking agent.

12. The product of claim 11, wherein the taste masking agent is selected from the group consisting of zinc gluconate, ethyl maltol, glycine, acesulfame-k, aspartame, saccharin, fructose, xylitol, isomalt, maltitol, spray dried licorice root, glycerrhizine, sodium gluconate, glucono delta-lactone, ethyl vanillin, dextrose, sucralose, vanillin, ethyl maltol, and combinations thereof.

13. The product of claim 11, wherein the taste masking agent comprises approximately 30% to about 99% by weight of the coating.

14. The product of claim 9, wherein the coating comprising approximately 0.1% to about 5% by weight of a high-intensity sweetener selected from the group consisting of aspartame, sucralose, saccharine, acesulfame-k, and combinations thereof.

15. The product of claim 9, wherein the center includes dextrose.

16. The product of claim 9, wherein the coating does not have a shellac layer.

17. A product including a medicament that has acceptable organoleptic properties comprising:

a compressed center that is defined by at least one excipient; and

a coating that at least substantially surrounds the center and comprising a medicament, the coating comprising at least 50% of the product by weight.

18. The product of claim 17, wherein the medicament is selected from the group consisting of analgesics, muscle relaxants, antibiotics, antivirals, stimulants, antihistamines, decongestants, anti-inflammatories, antacids, psychotherapeutic agents, insulin, vitamins, minerals, nutraceuticals, nutritional supplements, cardiovascular agents, and combinations thereof.

19. The product of claim 17, wherein the excipient is selected from the group consisting of saccharides, sugar alcohols, and combinations thereof.

20. The product of claim 17, wherein a taste masking agent comprises approximately 30% to about 99% by weight of the coating.

21. The product of claim 17, wherein the coating compromises approximately 0.1% to about 5% by weight of a high-intensity sweetener selected from the group consisting of aspartame, sucralose, saccharine, acesulfame-k, and combinations thereof.