CALCITONIN DRUG-OLIGOMER CONJUGATES, AND USES THEREOF
First Claim
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1. A monodispersed calcitonin-oligomer conjugate comprising salmon calcitonin coupled to two oligomer subunits, wherein each oligomer consists of the structure of Formula I:
- and wherein the first oligomer subunit is covalently coupled to Lys11 of said salmon calcitonin and the second oligomer is covalently coupled to Lys18 of said salmon calcitonin.
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Abstract
Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.
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Citations
4 Claims
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1. A monodispersed calcitonin-oligomer conjugate comprising salmon calcitonin coupled to two oligomer subunits, wherein each oligomer consists of the structure of Formula I:
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and wherein the first oligomer subunit is covalently coupled to Lys11 of said salmon calcitonin and the second oligomer is covalently coupled to Lys18 of said salmon calcitonin. - View Dependent Claims (2, 3, 4)
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Specification