INHIBITION OF PPAR GAMMA EXPRESSION BY SPECIFIC OSTEOGENIC OXYSTEROLS
First Claim
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1. A method for inhibiting expression of a peroxisome proliferator activated receptor (PPAR) in a cell, comprising:
- contacting at least one oxysterol compound with the cell in an amount effective to inhibit expression of the PPAR; and
measuring inhibition of expression of the PPAR.
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Abstract
This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
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Citations
44 Claims
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1. A method for inhibiting expression of a peroxisome proliferator activated receptor (PPAR) in a cell, comprising:
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contacting at least one oxysterol compound with the cell in an amount effective to inhibit expression of the PPAR; and measuring inhibition of expression of the PPAR. - View Dependent Claims (2, 3, 4, 5, 8, 11, 15, 16, 18, 19, 20, 21)
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6-7. -7. (canceled)
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9-10. -10. (canceled)
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12-14. -14. (canceled)
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17. (canceled)
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22. A method of treating a condition associated with increased adipogenesis in a subject, comprising administering to the subject an amount of an oxysterol compound effective to treat the condition, wherein the oxysterol compound has been shown to be in an amount that is effective to inhibit PPAR expression.
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23-25. -25. (canceled)
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26. A method of treating a condition associated with excessive accumulation of intracellular and/or extracellular fats and/or lipids in a subject, comprising administering to the subject an amount of an oxysterol compound effective to treat the condition, wherein the oxysterol compound has been shown to be in an amount that is effective to inhibit PPAR expression.
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27-34. -34. (canceled)
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35. A kit, comprising:
a dosage form of a pharmaceutical composition comprising an oxysterol compound effective to inhibit expression of PPAR, in a container.
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36. (canceled)
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37. A method for identifying an oxysterol compound that inhibits expression of PPAR, comprising:
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screening a candidate oxysterol compound for the ability to inhibit expression of PPAR in an in vitro assay; and selecting a candidate oxysterol compound that measurably inhibits PPAR expression. - View Dependent Claims (40, 41, 44)
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38-39. -39. (canceled)
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42-43. -43. (canceled)
Specification