METHODS AND APPARATUS FOR NONINVASIVE ISCHEMIC CONDITIONING
First Claim
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1. A method for an ischemic conditioning treatment in a patient comprising:
- causing ischemia by interrupting blood flow to a tissue,sensing markers of one or more of ischemia, blood flow, and metabolism in the tissue, andadjusting the ischemia based on the sensed results.
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Abstract
A method for ischemic conditioning treatment in a patient is provided. Transient ischemia is caused by interrupting blood flow to a tissue and a response to the ischemic conditioning treatments is monitored and the ischemia and response thereto is adjusted and controlled based on the monitoring results.
64 Citations
26 Claims
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1. A method for an ischemic conditioning treatment in a patient comprising:
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causing ischemia by interrupting blood flow to a tissue, sensing markers of one or more of ischemia, blood flow, and metabolism in the tissue, and adjusting the ischemia based on the sensed results. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A device for inducing ischemic conditioning, comprising:
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an occluding member adapted to occlude a blood vessel and cause ischemia; a sensor to monitor a response to the ischemic conditioning treatments, wherein the monitored response is one or more of markers of ischemia, blood flow and metabolism in a tissue distal to the occlusion; a programmable controlling member to control frequency and duration of ischemia in a tissue according to an ischemic conditioning protocol based on the monitored response; and a data storage member to store the ischemic conditioning protocol, monitored response, and/or combinations thereof. - View Dependent Claims (15, 16, 17)
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18. A device for inducing ischemic conditioning, comprising:
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an occluding member adapted to occlude a blood vessel and cause ischemia; a programmable controlling member to control frequency and duration of ischemia in a tissue according to a protocol based on an algorithm that is obtained from a multivariate prediction model of the extent of tissue ischemia during vessel occlusion; and a data storage member to store the ischemic conditioning protocol, monitoring results, or combinations thereof. - View Dependent Claims (19, 20, 21, 22, 23)
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24. A method for an ischemic conditioning treatment in a patient comprising:
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causing ischemia by interrupting blood flow to a tissue utilizing an controlled occluding device, wherein the blood flow is interrupted at least once in a period of 72 hours prior to an anticipated injury, surgical intervention, or medical intervention, monitoring one or more of tissue markers of ischemia;
markers of metabolism; and
markers of blood flow or pulse in the patient, andadjusting the extent, duration, frequency, or combinations thereof, of ischemia based on the monitoring results. - View Dependent Claims (25, 26)
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Specification