DRUG ADMINISTRATION BASED ON A PATIENT'S ACTIVITY STATUS MEASURED BY ACCELERATION SENSORS

• US 20100106076A1
• Filed: 03/21/2008
• Published: 04/29/2010
• Est. Priority Date: 03/27/2007
• Status: Abandoned Application

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Nisato, Giovanni, Kassies, Roelf, Van Herk, Johannes Johanna
• Application Number:
  US12/593,123
• Publication Number:
  US 20100106076A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

It is described a drug delivery system (100) that is adapted to infuse a drug in a profile related to the activity status of a patient (595). The system comprises acceleration sensors (112), dedicated electronics (120) and software to monitor the patient'"'"'s activity and maintain control over the drug-release profile. The described system (100) enables a personalized treatment of patients (595) by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) maybe realized as a closed-loop system for monitoring and treatment of various diseases such as Parkinson s disease. Accelerations sensors (112) may be used in order to directly monitor a positional state and/or motions of the patient'"'"'s body. The described system may allow for a more efficient use of the delivered drugs. This will result both in a reduction of the amount of required medication and a reduction of power required by the system (100).

Claims

1. A system for delivering at least one drug to the body of a patient (595), the system (100) comprising

a measurement device (112) for measuring at least one value of a parameter, which is indicative for the activity status of the patient (595),

a control unit (120), which is coupled to the measurement device (112) and which is adapted to determine a control signal based on the value of the parameter, and

a drug delivery device (150, 450, 550), which is coupled to the control unit (120) and which is adapted to deliver at least one drug to the patient'"'"'s body (595) based on the control signal,

wherein the measurement device (112) comprises a plurality of acceleration sensors (512).

2. The system according to claim 1, wherein

the control unit is adapted to determine the control signal in real time.

3. The system according to claim 1, wherein

the control unit is adapted to determine the control signal based on the current time of day.

4. The system according to claim 1, further comprising

a memory (120) for storing a plurality of values of the parameter, which values are indicative for the activity status of the patient (595), wherein the values have been acquired at different times.

5. The system according to claim 1, further comprising

a unit (120) for evaluating the frequency distribution (395) of a signal provided by the acceleration sensors (112).

6. The system according to claim 1, wherein

the measurement device (112), the control unit (120) and/or the drug delivery device (150) are designed to be externally and mechanically coupled to a patient'"'"'s body.

7. The system according to claim 1, wherein

the coupling between the measurement device (112), the control unit (120) and the drug delivery device (150) comprises a wireless connection.

8. The system according to claim 1, wherein

drug delivery device (150) is realized by a module, which can be spatially separated from the measurement device (112) and/or from the control unit (120).

9. The system according to claim 11, wherein

the drug delivery device (150) is a micro jet based device (450).

10. The system according to claim 11, wherein

the drug delivery device (150) is an iontophoretic device.

11. The system according to claim 1, wherein

the measurement device (112) comprises a magnetic field sensor.

12. The system according to claim 1, wherein

the measurement device (112) comprises a skin impedance sensor (754).

13. The system according to claim 1, wherein

the measurement device (112) comprises a heart rate sensor and/or a sweat sensor.

14. The system according to claim 1, further comprising

a communication unit (120), which is coupled to the control unit.

15. A method for delivering at least one drug to the body of a patient (595), the method comprising

measuring at least one value of a parameter by means of a plurality of acceleration sensors (512), which parameter is indicative for the activity status of the patient (595),

determining a control signal based on the value of the parameter, and

delivering drugs to the patient'"'"'s body (595) based on the control signal.