Systems and Methods for Aneurysm Treatment and Vessel Occlusion

• US 20100106240A1
• Filed: 10/20/2009
• Published: 04/29/2010
• Est. Priority Date: 10/20/2008
• Status: Active Grant

• Current Assignee: 2377469 Ontario Incorporated
• Original Assignee: IMDS Corporation
• Inventors: Lee, Donald H., De Hoog, Robert John, Butters, Joshua A., Duggal, Neil, Raymond, Louise C.
• Granted Patent: US 8,470,013 B2
• Time in Patent Office: Days
• US Class Current: 623/1.150
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12168 having a mesh structure A61B17/1214 takes precedence
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/856 Single tubular stent with a side portal passage
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2002/828 Means for connecting a plurality of stents allowing flexibility of the whole structure

Abstract

A system for treating an aneurysm includes an expandable barrier positionable to bridge an aneurysm neck. The barrier may comprise a fiber mesh, a balloon or a molly anchor member, and may unroll, unfold, or inflate from a compact configuration to an expanded configuration. Expansion of the barrier may be greater radially than axially. A vaso-occlusive member comprising a coil or balloon may be deposited in the aneurysm. Another aneurysm treatment system comprises an outer fenestrated stent and/or an inner fenestrated sleeve, which may be implanted together adjacent an aneurysm neck to regulate blood flow to the aneurysm. The sleeve may be movable relative to the stent to open or occlude the fenestrations, which may vary in size, shape, and distribution. An intra-luminal vessel occlusion device comprises a stent and a sheath. A drawstring may be actuated to gradually close a sheath orifice to control blood flow through the vessel.

Claims

1. A system for treating an aneurysm in a parent vessel, the parent vessel defining a lumen and having a lumen wall, the aneurysm having a neck communicating with the lumen, the system comprising:

a flexible stent configured for placement in the parent vessel adjacent the aneurysm neck, the stent comprising a first end and a second end and a stent wall extending therebetween defining a bore, the stent wall permeable to blood flow; and

a implantable barrier device configured for placement within the aneurysm neck and adjacent the stent, the barrier device comprising a first compact configuration and a second expanded configuration, the barrier device impermeable to blood flow in the second expanded configuration;

wherein in the second expanded configuration, the barrier device is shaped to extend across the aneurysm neck to prevent blood flow through the aneurysm neck.

2. The system of claim 1, wherein the barrier device is configured to radially expand from the first compact configuration to the second expanded configuration.

3. The system of claim 1, wherein the barrier device is configured to unroll or unfold from the first compact configuration to the second expanded configuration.

4. The system of claim 1, wherein the barrier device comprises a fiber mesh, the fiber mesh comprising strands chosen from the group consisting of:

nylon, polypropylene, polyester, polyurethane, polyvinyl chloride, Teflon, ePTFE, PTFE, polyethylene, polypropylene, silicone, PEEK, and hydrogel.

5. The system of claim 1, wherein the barrier device comprises an elastomeric sheath.

6. The system of claim 1, the system further comprising:

a vaso-occlusive device, the vaso-occlusive device configured to be deliverable into the aneurysm, wherein when the vaso-occlusive device is in the aneurysm and the barrier device is extended across the aneurysm neck in the second configuration, the barrier device retains the vaso-occlusive within the aneurysm.

7. The system of claim 6, wherein the vaso-occlusive device comprises a coil or braid.

8. The system of claim 6, wherein the barrier is connected to the vaso-occlusive device, and wherein the barrier and the vaso-occlusive device are configured to be deliverable together through a microcatheter.

9. A method for treating an aneurysm in a parent vessel, the parent vessel defining a lumen and having a lumen wall, the aneurysm having a neck communicating with the lumen, the method comprising:

introducing a flexible stent into the parent vessel;

positioning the flexible stent in the parent vessel adjacent the aneurysm neck, the stent comprising a first end and a second end and a stent wall extending therebetween defining a bore, the stent wall permeable to blood flow;

introducing a barrier device into the aneurysm neck and adjacent the stent wall, the barrier device in a first compact configuration;

transforming the barrier device from the first compact configuration to a second expanded configuration such that the barrier device extends across the aneurysm neck to prevent blood flow into the aneurysm.

10. The method of claim 9, wherein transforming the barrier device from the first compact configuration to the second expanded configuration comprises radially expanding the barrier device.

11. The method of claim 9, wherein transforming the barrier device from the first compact configuration to the second expanded configuration comprises unrolling or unfolding the barrier device.

12. The method of claim 9, wherein the barrier device comprises a fiber mesh, the fiber mesh comprising strands chosen from the group consisting of:

nylon, polypropylene, polyester, polyurethane, polyvinyl chloride, Teflon, ePTFE, PTFE, polyethylene, polypropylene, silicone, PEEK, and hydrogel.

13. The method of claim 9, wherein the barrier device comprises an elastomeric sheath.

14. The method of claim 9, further comprising:

introducing a vaso-occlusive device into the aneurysm through the aneurysm neck, wherein when the vaso-occlusive device is in the aneurysm and the barrier device is extended across the aneurysm neck in the second configuration, the barrier device retains the vaso-occlusive within the aneurysm.

15. The method of claim 14, wherein the barrier is connected to the vaso-occlusive device;

and wherein introducing the vaso-occlusive device comprises delivering the vaso-occlusive device and the barrier together.

16. The method of claim 9, wherein introducing the barrier device comprises delivering the barrier device through the parent vessel to the aneurysm neck in a microcatheter;

and

wherein transforming the barrier device comprises expelling the barrier from the microcatheter.

17. A system for treating an aneurysm in a parent vessel, the parent vessel defining a lumen and having a lumen wall, the aneurysm having a neck communicating with the lumen, the system comprising:

a flexible stent configured for placement in the parent vessel adjacent the aneurysm neck, the stent comprising a first end and a second end and a stent wall extending therebetween defining a bore, the stent wall permeable to blood flow;

a vaso-occlusive device configured to be introduced into the aneurysm; and

a implantable barrier device configured for placement within the aneurysm neck and adjacent the stent, the barrier device extendible across the aneurysm neck to prevent blood flow into the aneurysm and retain the vaso-occlusive device within the aneurysm.

18. The system of claim 17, wherein the vaso-occlusive device is a coil or braid.

19. The system of claim 17, wherein the barrier device is transformable from a first compact configuration to a second expanded configuration.

20. The system of claim 17, wherein the barrier device comprises a fiber mesh, the fiber mesh comprising strands chosen from the group consisting of:

nylon, polypropylene, polyester, polyurethane, polyvinyl chloride, Teflon, gold, platinum, platinum/iridium alloy, nitinol, and stainless steel.

21. The system of claim 17, wherein the barrier device comprises an elastomeric sheath.

22. The system of claim 17, wherein the barrier is integrally formed with the vaso-occlusive device.

23. A method for treating an aneurysm in a parent vessel, the parent vessel defining a lumen and having a lumen wall, the aneurysm having a neck communicating with the lumen, the method comprising:

introducing a flexible stent into the parent vessel;

positioning the flexible stent in the parent vessel adjacent the aneurysm neck, the stent comprising a first end and a second end and a stent wall extending therebetween defining a bore, the stent wall permeable to blood flow;

introducing a barrier device into the aneurysm neck and adjacent the stent wall, the barrier device extending substantially across aneurysm neck,

introducing a vaso-occlusive device into the aneurysm through the aneurysm neck;

retaining the vaso-occlusive device within the aneurysm with the barrier device.

24. The method of claim 23, wherein the barrier device is introduced independently of the flexible stent and the vaso-occlusive device.

25. The method of claim 23, further comprising transforming the barrier device from a first compact configuration to a second expanded configuration.

26. The method of claim 23, wherein the vaso-occlusive device is introduced into the aneurysm before the barrier device is introduced into the aneurysm neck.

27. The method of claim 23, wherein the vaso-occlusive device is introduced into the aneurysm after the barrier device is introduced into the aneurysm neck.

28. The method of claim 23, wherein the vaso-occlusive device introduced into the aneurysm through the barrier device.

29. The method of claim 23, wherein the vaso-occlusive device introduced into the aneurysm through the stent wall.