DETERMINATION OF CONTROL PARAMETERS FOR IRRADIATION OF A MOVING TARGET VOLUME IN A BODY

• US 20100108903A1
• Filed: 02/19/2008
• Published: 05/06/2010
• Est. Priority Date: 03/23/2007
• Status: Active Grant

• Current Assignee: GSI Helmholtzzentrum FüR Schwerionenforschung GmbH (Government of Germany)
• Original Assignee: GSI Helmholtzzentrum FüR Schwerionenforschung GmbH (Government of Germany), Siemens AG
• Inventors: Rietzel, Eike, Bert, Christoph, Kraft, Gerhard
• Granted Patent: US 8,299,448 B2
• Time in Patent Office: Days
• US Class Current: 250/396.R
• CPC Class Codes: A61N 2005/1052 using positron emission tomography [PET] single photon emission computer tomography [SPECT] imaging
• CPC Class Codes: A61N 2005/1055 using magnetic resonance imaging [MRI]
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1043 Scanning the radiation beam, e.g. spot scanning or raster scanning
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment

Abstract

Abstract: A control parameter is determined for a system (10) for irradiating a predetermined target volume in a body (77) with a particle beam (75). The system is constructed to direct the particle beam at a multiplicity of target points (30) in the target volume in succession in order to produce at, each of the target points a predetermined dose distribution (42) in a region around the target point. The control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighbouring target points. For determination of the control parameter, there is first determined (94) a movement parameter which quantitatively characterises the movement of the body at the first target point. The control parameter is determined (95) in dependence on the movement parameter.

Claims

1. Method of determining a control parameter of a system for irradiating a predetermined target volume in a body with a particle beam, the system being constructed to direct the particle beam at a multiplicity of target points in the target volume in succession in order to produce at each of the target points a predetermined dose distribution in a region around the target point, wherein the control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighbouring target points, comprising the following steps:

determination of a movement parameter which quantitatively characterises the movement of the body at the first target point;

determination of the control parameter in dependence on the movement parameter.

2. Method according to claim 1, wherein the control parameter is provided for controlling the extension of the dose distribution at the first target point and/or the spacing of the first target point from neighbouring target points.

3. Method according to claim 1, wherein the control parameter is provided for controlling the lateral profile of the particle beam at the first target point.

4. Method according to claim 1, wherein the control parameter is provided for controlling the width of a Bragg peak of the particle beam at the first target point.

5. Method according to claim 1, wherein a plurality of images of the body which have been determined at different points in time before the irradiation enter into the determination of the movement parameter.

6. Method according to claim 1, wherein an image of the body during the irradiation enters into the determination of the movement parameter.

7. Method according to claim 1, wherein a measurement signal of a sensor which detects the movement of the body enters into the determination of the movement parameter.

8. Method according to claim 1, wherein the movement parameter characterises an amplitude or speed of the movement.

9. Method according to claim 1, wherein the movement parameter characterises the movement of the body only in a time interval in which the body is in a movement state from a predetermined set of movement states.

10. Method according to claim 9, wherein the predetermined set of movement states includes movement states in which disparities in the local total dose with respect to a desired value that result from the movement of the body can be held within a given range by means of a given maximum overlap of the dose distributions at the target points.

11. Method according to claim 9, wherein the control parameters are provided for the control of an irradiation which takes place only in the time interval in which the body is in a movement state from the predetermined set of movement states.

12. Method according to claim 1, wherein the control parameter is additionally varied in dependence on the depth of a target point to be irradiated or on the particle energy.

13. Method according to claim 12, wherein the control parameter is varied so that the extent of the overlap of the dose distributions of neighbouring target points is greater in the case of a more deeply located target point than in the case of a less deeply located target point or is greater in the case of a higher particle energy than in the case of a lower particle energy.

14. Apparatus for determination of a control parameter of a system for irradiating a predetermined target volume in a body with a particle beam, the system being constructed to direct the particle beam at a multiplicity of target points in the target volume in succession in order to produce at each of the target points a predetermined dose distribution in a region around the target point, wherein the control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighbouring target points, having the following features:

an input for receiving a movement parameter which characterises the movement of the body at the first target point;

a device for determination of the control parameter in dependence on the movement parameter.

15. Apparatus according to claim 14, wherein the control parameter is provided for controlling the extension of the dose distribution at the first target point and/or the spacing of the first target point from neighbouring target points.

16. Apparatus according to claim 14, wherein the control parameter is provided for controlling the lateral profile of the particle beam at the first target point.

17. Apparatus according to claim 14, wherein the control parameter is provided for controlling the width of a Bragg peak of the particle beam at the first target point.

18. Apparatus according to claim 14, further having:

a device for receiving a plurality of images of the body which have been determined at different points in time before the irradiation and for determination of the movement parameter in dependence on the image.

19. Apparatus according to claim 14, further having:

a device for receiving an image of the body during the irradiation and for determination of the movement parameter in dependence on the image.

20. Apparatus according to claim 14, further having:

a device for receiving a measurement signal of a sensor which detects the movement of the body and for determination of the movement parameter in dependence on the measurement signal.

22. Apparatus according to claim 14, wherein the apparatus is a therapy planning apparatus.

23. Apparatus according to claim 14, wherein the device for determination of the control parameter is constructed to vary the control parameter additionally in dependence on the depth of a target point to be irradiated or on the particle energy.

24. Apparatus according to claim 23, wherein the device for determination of the control parameter is constructed to vary the control parameter so that the extent of the overlap of the dose distributions of neighbouring target points is greater in the case of a more deeply located target point than in the case of a less deeply located target point or is greater in the case of a higher particle energy than in the case of a lower particle energy.

25. System for irradiating a predetermined target volume in a body with a particle beam, the system directing the particle beam at a multiplicity of target points in the target volume in succession in order to produce at each of the target points a predetermined dose distribution in a region around the target point, wherein the control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighbouring target points, and wherein the system comprises an apparatus according to claim 14.

21. (canceled)