INTEGRATED BIO-CHIP, METHOD OF FABRICATING THE INTEGRATED BIO-CHIP, AND APPARATUS FOR DETECTING BIO-MATERIAL
First Claim
1. An integrated bio-chip comprising:
- a substrate including one or more reaction regions on which samples are disposed; and
one or more excitation light absorbing waveguides disposed in the substrate, whereina first end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof,a second end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof,the one or more reaction regions are disposed at the upper surface of the substrate,the one or more excitation light absorbing waveguides absorbs excitation light which excites the samples, andthe one or more excitation light absorbing waveguides transmits fluorescent light emitted from the samples.
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Accused Products
Abstract
An integrated bio-chip includes a substrate and one or more excitation light absorbing waveguides disposed in the substrate. The substrate includes one or more reaction regions on which samples are disposed. An end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof, another end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof, and the one or more reaction regions are disposed at a upper surface of the substrate. The one or more excitation light absorbing waveguides absorbs excitation light incident to the samples, and transmits fluorescent light emitted from the samples.
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Citations
32 Claims
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1. An integrated bio-chip comprising:
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a substrate including one or more reaction regions on which samples are disposed; and one or more excitation light absorbing waveguides disposed in the substrate, wherein a first end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof, a second end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof, the one or more reaction regions are disposed at the upper surface of the substrate, the one or more excitation light absorbing waveguides absorbs excitation light which excites the samples, and the one or more excitation light absorbing waveguides transmits fluorescent light emitted from the samples. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of fabricating an integrated bio-chip, the method comprising:
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forming one or more penetration holes in a substrate; forming one or more excitation light absorbing waveguides in the one or more penetration holes; and treating a surface of the substrate in which the one or more penetration holes are formed such that samples are attachable to reaction regions at which the one or more excitation light absorbing waveguides are formed. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An apparatus for detecting bio-material using an integrated bio-chip comprising a substrate including one or more reaction regions on which samples are disposed and one or more excitation light absorbing waveguides disposed in the substrate, the apparatus comprising:
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an illuminating optical system which irradiates excitation light onto the integrated bio-chip; a stage detachably mounted to the integrated bio-chip; and a photodetector which detects fluorescent light emitted from the integrated bio-chip, wherein a first end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at an upper surface thereof, a second end portion of each of the one or more excitation light absorbing waveguides is exposed from the substrate at a lower surface thereof, the one or more reaction regions are disposed at the upper surface of the substrate, the one or more excitation light absorbing waveguides absorbs excitation light which excites the samples, and the one or more excitation light absorbing waveguides transmits the fluorescent light emitted from the samples. - View Dependent Claims (28, 29, 30, 31, 32)
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Specification